Intranasal midazolam for anxiolysis in closed reduction of nasal fractures in children

Plum, Ann W.; Harris, Tucker M.

doi:10.1016/j.ijporl.2015.05.006

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…The results showed that midazolam was quite effective in providing effective anxiolysis and had no adverse outcomes. 20 In a 2015 study, Musani et al Concluded that intravenous midazolam had a quick onset of action and a quick recovery from sedation. Also, its proper effect required a lower dose through the intranasal route.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of oral diphenhydramine and midazolam on sedation of children

Bafghi

NaeimiBafghi

Salajegheh

2021

J. Contemp. Med. Sci.

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Objectives: The aim of this study was to compare the effect of diphenhydramine and midazolam on sedation of children. Methods: This clinical trial was performed on children aged 1 to 7 years who referred to the emergency department for diagnostic radiology. Patients were randomly divided into two groups of midazolam and diphenhydramine. Then, 30 minutes before the start of the procedure, 0.5 mg /kg was given to the midazolam group and 0.5 cc /kg to the diphenhydramine group. If sedation occurred, the child was separated from the parents and transferred to a diagnostic procedure. After performing the intended diagnostic procedure, the information sheet was completed and the patient's vital signs were checked again. The data were then analyzed by SPSS version 19 software. Results: A total of 74 patients were included in the study. There was no significant difference between the two groups in terms of age and gender (P = 0.89; P = 0.32). The mean sedation in the midazolam and diphenhydramine groups was 1.02 and 1.59 years, respectively. A significant difference was found between the two groups in terms of sedation (P = 0.04), where a greater effect of diphenhydramine on sedation was observed. Conclusion: The findings showed that the use of diphenhydramine resulted in effective sedation for children. Due to the fact that the main problem with midazolam is its bitter taste, which makes children reluctant to eat it, the use of diphenhydramine can be recommended.

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Section: Discussionmentioning

confidence: 99%

Comparison of the effect of oral diphenhydramine and midazolam on sedation of children

Bafghi

NaeimiBafghi

Salajegheh

2021

J. Contemp. Med. Sci.

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“…[ 15 ] The results of a case series by Plum and Harris on two pediatric patients with nasal fractures showed that intranasal midazolam can offer effective anxiolysis for pediatric patients during reduction of nasal fractures. [ 16 ] Likewise, Rostaminejad et al . in Iran recommended administration of intranasal midazolam before anesthesia for children aged 2–6 years.…”

Section: Introductionmentioning

confidence: 99%

Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial

Mayel¹,

Nejad

Khabaz

et al. 2020

Turk J Emerg Med

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OBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one of the most important factors that should be considered in pediatric emergencies. The aim of this study was to compare the efficacy of oral versus intranasal midazolam in sedation during radiologic imaging in the largest province of Iran, Kerman. MATERIALS AND METHODS: Eighty children were enrolled in this single-blind clinical trial based on convenience sampling and were divided into two groups receiving 0.5 mg/kg midazolam in oral route administration and 0.2 mg/kg midazolam in intranasal route administration. Finally, 75 patients remained for evaluating medication acceptability, sedation level, onset time of sedation, additional sedative dose, adverse effects of sedation, and provider satisfaction. RESULTS: Children in the intranasal group accepted medication more easily (89.8% vs. 36.9%; P ≤ 0.001), while these children received a lower sedation dose, but the sedation level in both methods was similar ( P = 0.72). Our findings showed that children in the intranasal sedation group had a faster onset of sedation compared to the oral group (17.94 ± 8.99 vs. 34.50 ± 11.45; P ≤ 0.001). The frequency of midazolam side effects had no difference between the groups (29.7% vs. 15.8%; P = 0.15). CONCLUSION: Intranasal midazolam with a lower sedation dose induces a faster onset and better acceptance. Intranasal midazolam can be used as an effective sedative method for pediatric patients, especially in emergency wards.

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“…NBFs are usually treated as outpatients' cases and considered minor injuries, [4,5] though NBFs can result in significant cosmetic and functionaldeformity [6].…”

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confidence: 99%

Analysis of Nasal Bone Fractures: Etiological and Demographic Characteristics

Allam

bakry

Abdelmegeed

2021

The Egyptian Journal of Plastic and Reconstructive Surgery

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Intranasal midazolam for anxiolysis in closed reduction of nasal fractures in children

Cited by 8 publications

References 8 publications

Comparison of the effect of oral diphenhydramine and midazolam on sedation of children

Comparison of the effect of oral diphenhydramine and midazolam on sedation of children

Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial

Analysis of Nasal Bone Fractures: Etiological and Demographic Characteristics

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