Intranasal Lidocaine in Acute Treatment of Migraine: A Randomized Controlled Trial

Avcu, Nazire; Doğan, Nurettın Özgür; Pekdemir, Murat; Yaka, Elif; Yılmaz, Serkan; Alyeşil, Cansu; Akalın, Latif Erdem

doi:10.1016/j.annemergmed.2016.09.031

Cited by 21 publications

(39 citation statements)

References 14 publications

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“…Of the 363 articles identified in the search, 34 were screened for eligibility, of which six fulfilled the specified inclusion criteria and 28 were excluded (Figure ) . Characteristics of the six included studies are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Each study used the International Headache Society (IHS) criteria to classify patients’ headaches. Of the six included studies, four enrolled only patients with migraine headache, one enrolled patients with migraine, tension‐type, or cluster headache, and one enrolled patients with either primary (migraine or tension‐type) or secondary headaches . Lidocaine solution concentrations, dosing frequency, and administration varied.…”

Section: Resultsmentioning

confidence: 99%

“…Lidocaine solution concentrations, dosing frequency, and administration varied. The most consistently described method of administration was the Barre method, which requires patients to lay supine and to extend and rotate their head while medication is administered to the nostril ipsilateral to the side of headache pain, or into both nostrils sequentially in the case of bilateral headache. Lidocaine solution was administered as drops or via a spray or pump device .…”

Section: Resultsmentioning

confidence: 99%

“…The most consistently described method of administration was the Barre method, which requires patients to lay supine and to extend and rotate their head while medication is administered to the nostril ipsilateral to the side of headache pain, or into both nostrils sequentially in the case of bilateral headache. Lidocaine solution was administered as drops or via a spray or pump device . Dosing frequencies used were: one single dose in all patients; one dose, with a repeat dose at 2 minutes or 15 minutes if a minimum threshold of pain remained; and two doses in all patients .…”

Section: Resultsmentioning

confidence: 99%

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Intranasal Lidocaine for Acute Management of Primary Headaches: A Systematic Review

Dagenais

Zed

2018

Pharmacotherapy

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Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this systematic review was to evaluate the efficacy and safety of intranasal lidocaine in the acute management of primary headaches. The MEDLINE (1946 to May 2018), EMBASE (1974 to May 2018), Cochrane Central Register of Controlled Trials (2008 to May 2018), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to May 2018), and ClincialTrials.gov online databases were searched. Studies conducted in patients with acute primary headache were included if lidocaine was compared with placebo or alternative treatments, lidocaine dosing was specified, and patients' pain before and after treatment were clearly reported. Six studies met the inclusion criteria. Intranasal lidocaine demonstrated potential benefit over placebo in acute pain reduction and need for rescue medication only in the four studies deemed to be of poor quality, not in the two fair-quality studies. No study reported benefit in preventing headache recurrence or repeat visits to the emergency department. Lidocaine was associated with significantly higher rates of adverse events compared with placebo and may result in lower rates of patient satisfaction. There is insufficient evidence to support the use of intranasal lidocaine in acute management of primary headaches. Further research is warranted to better elucidate whether intranasal lidocaine has a role in the management of specific primary headache subtypes and whether there is an optimal regimen.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Intranasal Lidocaine for Acute Management of Primary Headaches: A Systematic Review

Dagenais

Zed

2018

Pharmacotherapy

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“…are quite variable. [3][4][5][6][7][8] Peripheral nerve blocks are an alternative to drugs for primary headaches. Local anesthetics and/or steroidal injections are used for this purpose.…”

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confidence: 99%