Intranasal insulin treatment partially corrects the altered gene expression profile in the hippocampus of developing rats with perinatal iron deficiency
Brian J. Sandri,
Kathleen Ennis-Czerniak,
Priya Kanajam
et al.
Abstract:Background: Perinatal iron deficiency (FeD) targets the hippocampus and leads to long-term cognitive deficits. Intranasal insulin administration improves cognitive deficits in adult humans with Alzheimer's disease and type 2 diabetes and could provide benefits in FeD-induced hippocampal dysfunction. Objective: Assess intranasal insulin administration on the hippocampal transcriptome in a developing rat model of perinatal FeD. Methods: Perinatal FeD was induced using low-iron diet from gestational day 3 until p… Show more
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