Intranasal infusion of melanocortin receptor four (MC4R) antagonist to rats ameliorates development of depression and anxiety related symptoms induced by single prolonged stress

Serova, Lidia; Lauková, Marcela; Alaluf, Lishay G.; Sabban, Esther L.

doi:10.1016/j.bbr.2013.05.006

Cited by 65 publications

(66 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total arm entries were also used as indicators of changes in locomotor activities of the rats. Risk assessment was defined as the rat poking its head or trunk into an open arm while its hind quarters were located in one of the closed arms (Serova et al ., 2013a). Anxiety index was calculated as follows:

\begin{matrix} left \\ Anxiety index \\ = 1 - [\frac{(\frac{Time spent in the open arms}{Total time on the maze}) + (\frac{Number of entries to the open arms}{Total exploration on the maze})}{2}] \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

“…Anxiety index values range from 0 to 1 where an increase in the index expresses increased anxiety-like behavior (Serova et al ., 2013a). Unprotected head dips were defined as peering over the edge of an open arm with head, neck, and shoulders.…”

Section: Methodsmentioning

confidence: 99%

“…Unprotected head dips were defined as peering over the edge of an open arm with head, neck, and shoulders. Increase in this parameter expresses decreased anxiety-like behavior (Serova et al ., 2013a). Grooming behavior has been reported to be a response to novelty or other stressors and might vary in accordance with stress intensity (Serova et al ., 2013a).…”

Section: Methodsmentioning

confidence: 99%

“…Single prolonged stress (SPS) has been found to reproduce the cardinal symptoms of PTSD (Serova et al ., 2014). SPS causing HPA axis dysregulation may lead to profound maladaptive changes manifested in behaviors that resemble anxiety and depression, thereby mimicking human mental disorders involving these states (Serova et al ., 2013a). …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

Lee

Sur

Yeom

et al. 2014

Biomolecules & Therapeutics

View full text Add to dashboard Cite

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitary-adrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.

show abstract

\begin{matrix} left \\ Anxiety index \\ = 1 - [\frac{(\frac{Time spent in the open arms}{Total time on the maze}) + (\frac{Number of entries to the open arms}{Total exploration on the maze})}{2}] \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

Lee

Sur

Yeom

et al. 2014

Biomolecules & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Interestingly, rats heterozygous for a loss-of-function mutation in MC4R have a blunted response to stress in terms of plasma ACTH and corticosterone release as well as reduced activation of the paraventricular nucleus of the hypothalamus and the medial amygdala (Ryan et al, 2014). Moreover, exposure to the intranasal MC4R antagonist HS014 prevents the development of anxiety- and depressive-like behaviors in rats (Serova et al, 2013). Thus, the melanocortins and MC4R in particular appear to play a key role in regulating the bidirectional relationship between obesity and mood disorders that remains to be further explored.…”

Section: Energetic Stressors Alter the Hpa Axismentioning

confidence: 99%

Energetic stress: The reciprocal relationship between energy availability and the stress response

Harrell

Gillespie

Neigh

2016

Physiology & Behavior

View full text Add to dashboard Cite

The worldwide epidemic of metabolic syndromes and the recognized burden of mental health disorders have driven increased research into the relationship between the two. A maladaptive stress response is implicated in both mental health disorders and metabolic disorders, implicating the hypothalamic-pituitary-adrenal (HPA) axis as a key mediator of this relationship. This review explores how an altered energetic state, such as hyper- or hypoglycemia, as may be manifested in obesity or diabetes, affects the stress response and the HPA axis in particular. We propose that changes in energetic state or energetic demands can result in “energetic stress” that can, if prolonged, lead to a dysfunctional stress response. In this review, we summarize the role of the hypothalamus in modulating energy homeostasis and then briefly discuss the relationship between metabolism and stress-induced activation of the HPA axis. Next, we examine seven mechanisms whereby energetic stress interacts with neuroendocrine stress response systems, including by glucocorticoid signaling both within and beyond the HPA axis; by nutrient-induced changes in glucocorticoid signaling; by impacting the sympathetic nervous system; through changes in other neuroendocrine factors; by inducing inflammatory changes; and by altering the gut-brain axis. Recognizing these effects of energetic stress can drive novel therapies and prevention strategies for mental health disorders, including dietary intervention, probiotics, and even fecal transplant.

show abstract

Obesity and Stress: The Melanocortin Connection

Singhal

Hill

2018

Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function

View full text Add to dashboard Cite

Intranasal infusion of melanocortin receptor four (MC4R) antagonist to rats ameliorates development of depression and anxiety related symptoms induced by single prolonged stress

Cited by 65 publications

References 75 publications

L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

Energetic stress: The reciprocal relationship between energy availability and the stress response

Obesity and Stress: The Melanocortin Connection

Contact Info

Product

Resources

About