Intranasal infusion of clotrimazole for the treatment of nasal aspergillosis in two cats

Furrow, Eva; Groman, Reid P.

doi:10.2460/javma.235.10.1188

Cited by 34 publications

(34 citation statements)

References 35 publications

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“…Although reported as a rare condition in cats, sino‐orbital aspergillosis is increasingly described in the published reports suggesting this may be an emerging disease 1–9 . Invasive mycotic infections in humans, as well as animals, can occur as either disseminated or localized forms.…”

Section: Introductionmentioning

confidence: 99%

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Smith¹,

Hoffman

2010

Veterinary Ophthalmology

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Feline orbital aspergillosis is increasingly described in the published reports and may be an emerging disease. Orbital mycotic infections were diagnosed in three cats with exophthalmos, significant dorso-temporal globe deviation and pronounced resistance to retropulsion. Advanced imaging was performed in all three cases to evaluate the extent of disease as well as to obtain guided orbital biopsies in two cases. Surgical intervention in the form of a lateral orbitotomy was pursued in the first case with the other two cases treated with enucleation or medical management alone. The available published reports concerning sino-orbital aspergillosis are reviewed. Oral therapy with a novel triazole, voriconazole, was instituted in two cases. Although voriconazole was apparently effective against the fungal organisms, it is also resulted in adverse reactions.

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Section: Introductionmentioning

confidence: 99%

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Smith¹,

Hoffman

2010

Veterinary Ophthalmology

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“…Feline upper respiratory tract aspergillosis (URTA), first described in 1982, (Wilkinson et al, 1982), is being increasingly reported (Barachetti et al, 2009;Barrs et al, 2012;Declercq et al, 2012;Furrow and Groman, 2009;Giordano et al, 2010;Kano et al, 2008;Kano et al, 2013;Karnik et al, 2009;Smith and Hoffman, 2010). Disease occurs over a wide geographic range, including Australia, the USA, the United Kingdom, mainland Europe, and Japan (Barrs et al, 2012;Barrs et al, 2013;Declercq et al, 2012;Goodall et al, 1984;Kano et al, 2013;Smith and Hoffman, 2010;Tomsa et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Descriptions of computed tomography (CT) findings in cats with URTA are limited to case reports (Barachetti et al, 2009;Furrow and Groman, 2009;Giordano et al, 2010;Halenda and Reed, 1997;Hamilton et al, 2000;Kano et al, 2008;McLellan et al, 2006;Smith and Hoffman, 2010;Whitney et al, 2005), and one case series of mycotic rhinitis that included five cats with URTA but did not distinguish between SNA and SOA or identify the aetiological agents (Karnik et al, 2009). The objectives of this study were to describe the CT features of URTA, to determine whether cats with SOA have concurrent 3 | P a g e involvement of the SNC, and to determine if there was any association between CT features and the form of aspergillosis and/or infecting species.…”

Section: Introductionmentioning

confidence: 99%

Computed tomographic features of feline sino-nasal and sino-orbital aspergillosis

Barrs

Beatty

Dhand

et al. 2014

The Veterinary Journal

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Makara, M. (2014). Computed tomographic features of feline sino-nasal and sino-orbital aspergillosis. Vet J. 201(2):215-22. DOI:10.1016DOI:10. /j.tvjl.2014 Computed tomographic features of feline sino-nasal and sino-orbital aspergillosis AbstractFeline upper respiratory tract aspergillosis (URTA) occurs as two distinct anatomic forms, sinonasal aspergillosis (SNA) and sino-orbital aspergillosis (SOA). An emerging pathogen, Aspergillus felis is frequently involved. The pathogenesis of URTA, in particular, the relationship between the infecting isolate and outcome, is poorly understood. Computed tomography was used to investigate the route of fungal infection and extension in 16 cases (SNA n=7, SOA n=9) where the infecting isolate had been identified by molecular testing.All cases had nasal cavity involvement except one cat with SNA that had unilateral frontal sinus changes. A strong association between the infecting species and anatomic form was identified. A. fumigatus infections remained within the sino-nasal cavity. Cryptic species infections were associated 2 | P a g e with orbital and paranasal soft-tissue involvement and with orbital lysis. These species were further associated with a mass in the nasal cavity, paranasal sinuses or nasopharynx. Orbital masses showed heterogeneous contrast enhancement, with central coalescing hypoattenuating foci and peripheral rim enhancement. Severe, cavitated turbinate lysis, typical of canine SNA, was present only in cats with SNA.These findings support that the nasal cavity is the portal of entry for fungal spores in feline URTA and that the route of extension to involve the orbit is via direct naso-orbital communication from bone lysis. Additionally, a pathogenic role for A. wyomingensis and a sinolith in a cat with A. udagawae infection are reported for the first time.

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“…Feline upper respiratory tract aspergillosis (URTA), which encompasses both sino-orbital aspergillosis (SOA) and sinonasal aspergillosis (SNA), is usually reported in immunocompetent cats. To date, only five of more than 60 cats with URTA have been identified as having concurrent, potentially immunosuppressive diseases including diabetes mellitus in three cats, feline immunodeficiency virus (FIV) infection in one and feline leukaemia virus (FeLV) infection in another (Goodall et al, 1984;Furrow and Groman, 2009;Malik et al, 2004;Barrs et al, 2015;Kano et al, 2015). Recent studies have also detected anti-Aspergillus spp.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Analysis of Leucocyte Subsets in the Sinonasal Mucosa of Cats with Upper Respiratory Tract Aspergillosis

Whitney

Krockenberger

Day

et al. 2016

Journal of Comparative Pathology

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SummaryLeucocyte populations in the sinonasal mucosa of cats with and without upper respiratory tract aspergillosis were compared using immunohistochemistry and computer-aided morphometry. Inflammation was identified in the nasal mucosa of all affected cats, comprising predominantly of lymphoplasmacytic infiltration of the lamina propria associated with epithelial proliferation and degeneration. There was intense and diffuse expression of class II antigens of the major histocompatibility complex, associated with sites of hyphal invasion with hyperplasia and ulceration of the epithelium adjacent to fungal elements.

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Intranasal infusion of clotrimazole for the treatment of nasal aspergillosis in two cats

Cited by 34 publications

References 35 publications

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Computed tomographic features of feline sino-nasal and sino-orbital aspergillosis

Immunohistochemical Analysis of Leucocyte Subsets in the Sinonasal Mucosa of Cats with Upper Respiratory Tract Aspergillosis

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