Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

Tamura, Shinichi; Ainai, Akira; Suzuki, Tadaki; Kurata, Takeshi; Hasegawa, Hideki

doi:10.7883/yoken.jjid.2015.560

Cited by 45 publications

(35 citation statements)

References 93 publications

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“…It is possible and likely helpful that for future IAV vaccines to incorporate specific strategies to stimulate some IAV‐specific mTregs. It would be more appealing if such vaccine is given via the intranasal route and induces lung‐resident mTregs as intranasal administration but not injection of influenza vaccines are more expected to improve the efficacy of influenza vaccines and generating lung‐resident memory T cells . Such IAV‐specific mTregs or lung‐resident mTregs might provide more timely immune regulation at the infection sites to minimize IAV infection‐caused immunopathology without significantly affecting immune protection provided by both innate and adaptive immune cells.…”

Section: Discussionmentioning

confidence: 99%

Memory regulatory T cells home to the lung and control influenza A virus infection

Zanker

Lock

et al. 2019

Immunol Cell Biol

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Memory regulatory T cells (mTregs) have been demonstrated to persist long‐term in hosts after the resolution of primary influenza A virus (IAV) infection. However, whether such IAV infection‐experienced (IAV‐experienced) mTregs differentiate into a phenotypically and functionally distinct Treg subset and what function they play at the infection site remains poorly defined. In this study, we characterized the phenotype, examined the responsiveness and assessed the suppressive function of IAV‐experienced memory Tregs (mTregs). In comparison with inexperienced naïve Tregs (nTregs), mTregs exhibited elevated expression of CD39, CD69, CD103, cytotoxic T lymphocyte‐associated antigen‐4, leukocyte function‐associated antigen‐1 and programmed cell death‐1 and could be activated in an antigen‐specific manner in vitro and in vivo. When mTregs and nTregs were adoptively cotransferred into recipient mice, mTregs had a competitive advantage in migrating to the IAV‐infected lungs. mTregs were more capable of controlling in vitro proliferation of CD4+ and CD8+ T cells and suppressed CD40 and CD86 upregulation on bone marrow‐derived dendritic cells. Adoptively transferred mTregs, but not adoptively transferred nTregs, significantly attenuated body weight loss, lung pathology and immune cell infiltration into the infected lungs after IAV infection. These results suggest that mTregs generated after IAV infection differentiate into a phenotypically distinct and functionally enhanced Treg subset that can be activated in an antigen‐specific manner to exert immunosuppression. We propose vaccination to induce such mTregs as a potential novel strategy to protect against severe IAV infection.

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Section: Discussionmentioning

confidence: 99%

Memory regulatory T cells home to the lung and control influenza A virus infection

Zanker

Lock

et al. 2019

Immunol Cell Biol

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“…Additionally, a decline in immune response in the innate and adaptive immune system in the elderly leads to greater susceptibility to infection and lower responsiveness to the vaccine. Critical characteristics of immunosenescence include, for example, decreased number and function of dendritic cells, an alteration in the number of natural killer cells, and a decreased number of naive T and B cells [6,17,18]. The major factors known to determine influenza vaccine response are summarized in Table 2.…”

Section: Role Of Host Immunity On Influenza Vaccine Responsementioning

confidence: 99%

Historical review on thymosin α1 in oncology: preclinical and clinical experiences

Garaci

Pica

Matteucci

et al. 2015

Expert Opinion on Biological Therapy

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Thymosin α1 (Tα1) is a naturally occurring polypeptide that regulates immune cell development and function, and is also capable of interacting with multiple target cells with relevant biological effects. The rationale of Tα1 use in cancer treatment stems from the consideration that tumor progression is favored by a failure of the immune response and in turn induces immune suppression. This paper will review the historical background of Tα1 use in oncology, aiming to highlight the importance of Tα1 as an immunotherapeutic tool to be used in combination with chemotherapy, a concept that is not yet fully established in clinic. Areas covered: The efficacy and safety of combining Tα1 with chemotherapy and cytokines were first evaluated in murine tumor models, providing essential information about effects, mechanisms of action, doses and treatment protocols. The therapeutic potential of the chemo-immunotherapy protocol on metastatic melanoma and lung cancer has been confirmed in controlled clinical trials. Critical for the efficacy of the chemo-immunotherapy protocol is the dual action of Tα1 on immune effector and tumor cells. Expert opinion: On the basis of the preclinical and clinical results available, the use of the chemo-immunotherapy protocol, in which the role of Tα1 is central, is strongly recommended

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“…To improve the protective efficacy of OmpK/Omp22 vaccination, the change in inoculation strategy needs to be analysed. Many studies suggest that vaccination at the mucosal site is superior to vaccination at other sites in eliciting protection for mucosal infectious diseases . Thus, it is believed that greater immune protection may be achieved if vaccine candidate against A baumannii is given mucosally via the respiratory tract .…”

Section: Introductionmentioning

confidence: 99%

MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice

Yang

SanJun

et al. 2019

Scand J Immunol

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Acinetobacter baumannii (A baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase in drug-resistant A baumannii strains makes it difficult to control by using common antibiotics. The development of effective vaccines is an alternative means to avoid A baumannii infections. In the present study, Balb/c mice were inoculated intratracheally with 30 μg of OmpK/

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Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

Cited by 45 publications

References 93 publications

Memory regulatory T cells home to the lung and control influenza A virus infection

Memory regulatory T cells home to the lung and control influenza A virus infection

Historical review on thymosin α1 in oncology: preclinical and clinical experiences

MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice

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