Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS

Belgamwar, Aarti; Khan, Shagufta; Yeole, Pramod

doi:10.1016/j.jddst.2019.06.014

Cited by 32 publications

(9 citation statements)

References 29 publications

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“…123 Some recent case studies of the CDs in the optimal drug delivery of drugs, proteins, peptides and aptamers are reported in the Table 3. [124][125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140] CDs can be moulded into various types of formulation for proving ease the drug delivery by diverse routes of administration.…”

Section: An Account Of Recent Advances In Cds For Optimal Drug Deliverymentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

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Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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Section: An Account Of Recent Advances In Cds For Optimal Drug Deliverymentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

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“…Furthermore, Belgamwar et al investigated the efficiency of dolutegravir sodium-loaded nanoparticles comprising hydroxypropyl-β-cyclodextrin cross-linked with diphenyl carbonate in order to enhance the central nervous system uptake through the intranasal administration route. Results proved an improved permeation of the drug through the nasal mucosa and access in the cerebrospinal fluid without damaging the mucosa [ 146 ].…”

Section: Antimicrobial Applications Of Polymeric Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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“…The sustained drug release observed could possibly be attributed to the cross-linked polymer network formed during the nanoprecipitation process, which caused the entrapped drug to diffuse slowly from the nanostructure. High brain–drug transport percentage was also observed [ 53 ]. Moreover, a group of scientists used cationic liposomes to penetrate the nasal mucus, and using acetylcholinesterase reactivator as a model drug, they probed its release from the nanoparticles.…”

Section: Excipients Used In Modified Drug Release Semi-solid Pharmace...mentioning

confidence: 99%

Excipients Used for Modified Nasal Drug Delivery: A Mini-Review of the Recent Advances

et al. 2022

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The ongoing challenging task in the field of nasal drug delivery is the maintenance of an efficient concentration of the active substance in the target area for an adequate period of time. Thus, there is an urgent need to develop effective new strategies for drug delivery to the nose, using cutting edge technology and materials for this particular type of drug delivery. This review gives an account of the critical components of nasal drug delivery and the parameters influencing drug absorption in the nose, including the excipients required for modified drug administration.

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Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS

Cited by 32 publications

References 29 publications

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Excipients Used for Modified Nasal Drug Delivery: A Mini-Review of the Recent Advances

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