Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children

Laube, Beth L.; Sharpless, Gail; Vikani, Ami R.; Harrand, Vincent J.; Zinreich, S J; Sedberry, Keith; Knaus, Darin A.; Barry, James J.; Papania, Mark J.

doi:10.1089/jamp.2014.1174

Cited by 16 publications

(7 citation statements)

References 37 publications

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“…These findings are most likely due to the child’s smaller nose geometry and narrower nasal valve. The authors explained the contradiction of their results compared with those of Laube et al [ 114 ] as being due to various factors that seem to have a significant impact on the deposition in the turbinate region such as the child’s age, anatomical differences, the device tip insertion depth and angle into nose nostril, and the released plume angle. The Accuspray™ device used in the by Laube et al was well-fitted into the nostril due to the flexibility of the nostril material and produced a narrower plume angle plume, allowing a greater jet fraction to enter the turbinate region beyond the nasal valve.…”

Section: Nasal Deposition Studies In Pediatricsmentioning

confidence: 78%

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery

2021

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The nasal cavity is an attractive route for both local and systemic drug delivery and holds great potential for access to the brain via the olfactory region, an area where the blood–brain barrier (BBB) is effectively absent. However, the olfactory region is located at the roof of the nasal cavity and only represents ~5–7% of the epithelial surface area, presenting significant challenges for the deposition of drug molecules for nose to brain drug delivery (NTBDD). Aerosolized particles have the potential to be directed to the olfactory region, but their specific deposition within this area is confounded by a complex combination of factors, which include the properties of the formulation, the delivery device and how it is used, and differences in inter-patient physiology. In this review, an in-depth examination of these different factors is provided in relation to both in vitro and in vivo studies and how advances in the fabrication of nasal cast models and analysis of aerosol deposition can be utilized to predict in vivo outcomes more accurately. The challenges faced in assessing the nasal deposition of aerosolized particles within the paediatric population are specifically considered, representing an unmet need for nasal and NTBDD to treat CNS disorders.

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Section: Nasal Deposition Studies In Pediatricsmentioning

confidence: 78%

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery

2021

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“…Para la segunda pulverización, se toma como la misma línea imaginaria, pero formando un ángulo de aproximadamente 45°respecto al dispositivo (Fig. 6-B), alcanzando la zona del meato medio 29,40 .…”

Section: Ubicación Del Dispositivo Intranasalunclassified

“…La correcta ubicación y angulación del dispositivo intranasal pueden contribuir al éxito anestésico, pues, en un estudio se menciona que la colocación del pulverizador en el interior de la vía aérea nasal principal obtiene mejores resultados de eficacia anestésica en comparación con la colocación a la entrada de la fosa nasal 40 .…”

Section: Ubicación Del Dispositivo Intranasalunclassified

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Anestesia dental local sin aguja: Una revisión integrativa de la literatura.

Alvarez-Sarmiento¹

2020

Odontol. Act.

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La anestesia local sigue siendo uno de los pilares de las técnicas de control del dolor en Odontología y, es ampliamente administrada empleando jeringuilla y aguja de inyección. Sin embargo, las técnicas anestésicas que no emplean aguja son también importantes elementos del arsenal odontológico para el control del dolor, aunque son poco conocidas y empleadas. El propósito de esta revisión es describir las técnicas anestésicas libres de aguja disponibles, así como sus dispositivos y perspectivas futuras. Se realizó una revisión integrativa de la literatura en el idioma inglés para evaluar las publicaciones de las últimas dos décadas, utilizando las bases de datos PubMed, Scopus, EBSCO, Science Direct y Wiley Online Library, empleando las siguientes palabras clave: anestesia dental local, anestesia sin aguja, anestesia dental a presión y anestesia intranasal. Se seleccionaron únicamente artículos y libros de mayor relevancia. Finalmente, se obtuvo 33 artículos y 1 libro. Las técnicas de anestesia dental sin aguja disponibles actualmente son: anestesia a presión, intrasulcular e intranasal, todas ellas emplean dispositivos diferentes y poseen aplicaciones, ventajas, desventajas y limitaciones inherentes que podrían ser mejoradas o superadas en un futuro próximo.

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“…The deposition of nasal sprays delivered from mechanical pump spray devices has been studied, both in vitro and in vivo, in children and adults, in order to identify the key factors required for efficient intranasal delivery (5)(6)(7)(8). Regardless of the experimental methodology, most sprays were observed to impact in the anterior regions of the nasal cavity with very little spray able to penetrate deep into the turbinate region of the main nasal cavity (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

A Simplified Geometric Model to Predict Nasal Spray Deposition in Children and Adults

et al. 2018

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A mathematical approach was developed to estimate spray deposition patterns in the nasal cavity based on the geometric relationships between the emitted spray plume and the anatomical dimensions of the nasal valve region of the nasal cavity. Spray plumes were assumed to be spherical cones and the nasal valve region was approximated as an ellipse. The effect of spray plume angle (15-85°) on the fraction of the spray able to pass through the nasal valve (deposition fraction) was tested for a variety of nasal valve (ellipse) shapes and cross-sectional areas based on measured dimensions from pediatric and adult nasal cavities. The effect of the distances between the tip of the nasal spray device and the nasal valve (0.2-1.9 cm) on the deposition fraction was also tested. Simulation results show that (1) decreasing spray plume angles resulted in higher deposition fractions, (2) deposition fraction was inversely proportional to the spray distance and the nasal valve (ellipse) major/minor axis ratio, and (3) for fixed major/minor axis ratios, improved deposition occurred with larger nasal valve cross-sectional areas. For a typical adult nasal valve, plume angles of less than 40° emitted from a distance of 1 cm resulted depositions greater than 90% within the main nasal cavity, whereas for a 12-year-old child, only the most narrow plume angles (< 20°) administered resulted in significant deposition beyond the nasal valve.

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Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children

Abstract: These results indicate that age and device placement play important roles in terms of intranasal deposition, when administering aerosol with Accuspray(™) to children.

Cited by 16 publications

References 37 publications

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery

Anestesia dental local sin aguja: Una revisión integrativa de la literatura.

A Simplified Geometric Model to Predict Nasal Spray Deposition in Children and Adults

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