Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model

Yousfan, Amal; Rubio, Noelia; Al-Ali, Mohammad; Nattouf, Abdul Hakim; Kafa, Houmam

doi:10.1039/d1bm01251g

Cited by 12 publications

(7 citation statements)

References 104 publications

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“…The duration of seizure stages and the total number of EEG signals per stage using equivalent doses of PHT over 1, 4, and 48 h (right). [ 89 ] Copyright 2021, The Royal Society of Chemistry. d) 3D printing of gummy drug formulations composed of gelatin and an HPMC‐based hydrogel for pediatric use.…”

Section: Bioinorganic Materials For Epilepsy Treatmentmentioning

confidence: 99%

“…Kafa et al utilized PHT‐loaded lecithin‐chitosan (L 10 C i + ) NPs to inhibit generalized tonic‐clonic seizures through IN administration. [ 89 ] The positive charge on the surface of NPs facilitated strong interaction with negatively charged nasal mucosa. The presence of abundant alcohol groups in the chitosan network promoted surface wetting, polymer dispersion, and enhanced PHT release.…”

Section: Bioinorganic Materials For Epilepsy Treatmentmentioning

confidence: 99%

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Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.

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Section: Bioinorganic Materials For Epilepsy Treatmentmentioning

confidence: 99%

Section: Bioinorganic Materials For Epilepsy Treatmentmentioning

confidence: 99%

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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“…The mouse model study demonstrated the potential of lecithin-chitosan nanoparticles (L10Ci+) as a non-invasive phenytoin (PHT) delivery method. This strategy shows the promise of nanomedicine in the treatment of epilepsy by enabling the effective management of the condition with lower doses of PHT [116].…”

Section: Clinical Studies and Patents Of Nanoformulationsmentioning

confidence: 99%

Nanotechnological advances in the treatment of epilepsy: a comprehensive review

Rai,

Sharma,

Bhasin

et al. 2024

Nanotechnology

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Epilepsy is one of the most prevalent chronic neurological disorders characterized by frequent unprovoked epileptic seizures. Epileptic seizures can develop from a broad range of underlying abnormalities such as tumours, strokes, infections, traumatic brain injury, developmental abnormalities, autoimmune diseases, and genetic predispositions. Sometimes epilepsy is not easily diagnosed and treated due to the large diversity of symptoms. Undiagnosed and untreated seizures deteriorate over time, impair cognition, lead to injuries, and can sometimes result in death. This review gives details about epilepsy, its classification on the basis of ILAE, current therapeutics which are presently offered for the treatment of epilepsy. Despite of the fact that more than 30 different AED and antiseizure drugs are available, large number of epileptic patients fail to attain prolonged seizure independence. Poor onsite bioavailability of drugs due to Blood Brain Barrier poses a major challenge in drug delivery to brain. The present review covers the limitations with the state-of-the-art strategies for managing seizures and emphasizes the role of nanotechnology in overcoming these issues. Various nano-carriers like polymeric nanoparticles, dendrimers, lipidic nanoparticles such as solid lipid nanoparticles, nano-lipid carriers, have been explored for the delivery of anti-epileptic drugs to brain using oral and intranasal routes. Nano-carries protect the encapsulated drugs from degradation and provide a platform to deliver controlled release over prolonged periods, improved permeability and bioavailability at the site of action. The review also emphasises in details about the role of neuropeptides for the treatment of epilepsy.

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“…developed another sort of NPs, based on chitosan loaded with phenytoin for epilepsy treatment, enabling an extraordinarily rapid time (< 5 min) for brain targeting drug administration via IN delivery. [ 138 ]…”

Section: Therapeutic Applications Of Modified Nps For Brain Diseasesmentioning

confidence: 99%

“…[137] In 2021, Yousfan et al developed another sort of NPs, based on chitosan loaded with phenytoin for epilepsy treatment, enabling an extraordinarily rapid time (< 5 min) for brain targeting drug administration via IN delivery. [138] The CUR-CS-PLGA-NPs are considered to be more effective in delivering curcumin to the brain via IN for the AD treatment, because these NPs possess excellent physiological stability (95%).…”

Section: Chitosan-modified Npsmentioning

confidence: 99%

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

Zha

Wong

All

2022

Adv Healthcare Materials

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Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for treating neurological disorders is often constrained by low delivery efficacy due to difficulties in passing the blood-brain barrier (BBB). Nanoparticles (NPs) administered intranasally can move along olfactory and trigeminal nerves so that they do not need to pass through the BBB, allowing non-invasive, direct access to selective neural pathways within the brain. Hence, intranasal (IN) administration of NPs can effectively deliver drugs and genes into targeted regions of the brain, holding potential for efficacious disease treatment in the central nervous system (CNS). In this review, current methods for delivering conjugated NPs to the brain are primarily discussed. Distinctive potential mechanisms of therapeutic nanocomposites delivered via IN pathways to the brain are then discussed. Recent progress in developing functional NPs for applications in multimodal bioimaging, drug delivery, diagnostics, and therapeutics is also reviewed. This review is then concluded by discussing existing challenges, new directions, and future perspectives in IN delivery of nanomaterials.

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Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model

Abstract: In this work we describe the preparation and characterization of lecithin-chitosan nanoparticles (L10Ci+), and investigate their ability to deliver the anti-epileptic drug phenytoin (PHT) to mouse brain following intranasal (IN)...

Cited by 12 publications

References 104 publications

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Nanotechnological advances in the treatment of epilepsy: a comprehensive review

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

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