Intranasal delivery of biotechnology-based therapeutics

Patel, Dhrumi; Patel, Bharvi; Wairkar, Sarika

doi:10.1016/j.drudis.2022.103371

Cited by 7 publications

(10 citation statements)

References 70 publications

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“…This approach provides a rapid achievement of a therapeutic effect, as well as non-invasiveness and ease of use compared to oral or injection methods of drug delivery. An important feature of intranasal administration is the absence of passage through the hepatic barrier, which allows the use of lower doses of drugs that reduce side effects [ 16 , 20 , 21 ].…”

Section: Insulin and Insulin Signaling System In The Brain And Intran...mentioning

confidence: 99%

“…The role of the “first violin” here is assigned to intranasally administered insulin (INI), the use of which allows you to quickly increase the level of the hormone in the brain and thereby stimulate insulin signaling in neurons [ 16 , 17 , 18 , 19 ]. Currently, the intranasal route of drug administration is being actively studied and considered for use in the clinic for the delivery of various hormones, growth factors, and pharmacological agents [ 20 , 21 , 22 , 23 ]. The pharmacokinetics and pharmacodynamics of INI have been extensively studied in the rodent models [ 16 , 17 , 18 , 19 ] and in human [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Zorina

Derkach

2023

IJMS

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A decrease in the activity of the insulin signaling system of the brain, due to both central insulin resistance and insulin deficiency, leads to neurodegeneration and impaired regulation of appetite, metabolism, endocrine functions. This is due to the neuroprotective properties of brain insulin and its leading role in maintaining glucose homeostasis in the brain, as well as in the regulation of the brain signaling network responsible for the functioning of the nervous, endocrine, and other systems. One of the approaches to restore the activity of the insulin system of the brain is the use of intranasally administered insulin (INI). Currently, INI is being considered as a promising drug to treat Alzheimer’s disease and mild cognitive impairment. The clinical application of INI is being developed for the treatment of other neurodegenerative diseases and improve cognitive abilities in stress, overwork, and depression. At the same time, much attention has recently been paid to the prospects of using INI for the treatment of cerebral ischemia, traumatic brain injuries, and postoperative delirium (after anesthesia), as well as diabetes mellitus and its complications, including dysfunctions in the gonadal and thyroid axes. This review is devoted to the prospects and current trends in the use of INI for the treatment of these diseases, which, although differing in etiology and pathogenesis, are characterized by impaired insulin signaling in the brain.

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Section: Insulin and Insulin Signaling System In The Brain And Intran...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Zorina

Derkach

2023

IJMS

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“…Finally, the recovery percentages of the powders in the child nasal replica cast were also close to 100%. trigeminal, and systemic pathways (Patel, Patel and Wairkar, 2022). Specifically, olfactory epithelium should be targeted in the olfactory pathway, maxillary and ophthalmic nerves should be targeted in the trigeminal pathway, and the capillary blood vessels in the nasal mucosa should be targeted for the systemic pathway (Patel, Patel and Wairkar, 2022).…”

Section: Deposition Patterns Of Tff Aug-3387c Powder In Nasal Replica...mentioning

confidence: 99%

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

Yu,

Xu,

AboulFotouh

et al. 2023

Preprint

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Monoclonal antibodies (mAbs) administered intranasally as dry powders can be potentially applied for the treatment or pre-exposure prevention of viral infections in the upper respiratory tract. However, a method to transform the mAbs from liquid to dry powders suitable for intranasal administration and a device that can spray the dry powders to the desired region of the nasal cavity are needed to fully realize the potentials of the mAbs. Herein, we report that thin-film freeze-drying can be applied to prepare aerosolizable mAb dry powders and that the dry powders can be sprayed into the posterior nasal cavity using the Unidose (UDS) Powder Nasal Spray System from Aptar Pharma. AUG-3387, a human-derived mAb that neutralizes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was used in the present study. First, we prepared AUG-3387 thin-film freeze-dried powders (i.e., TFF AUG-3387 powders) from liquid formulations containing different levels of mAbs. The TFF AUG-3387 powder with the highest solid content (i.e., TFF AUG-3387C powder) was then chosen for further characterization, including the evaluation of the plume geometry, spray pattern, and particle size distribution after the powder was sprayed using the UDS Powder device. Finally, the deposition patterns of the TFF AUG-3387C powder sprayed using the UDS Powder device were studied using 3D-printed nasal replica casts based on an adult model and a child model. It is concluded that it is feasible to intranasally deliver mAbs as dry powders by transforming the mAbs into dry powders using thin-film freeze-drying and then spray the powder using the UDS Powder device.

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“…Early intranasal administration was generally limited to the treatment of localized symptoms such as seasonal rhinitis or respiratory infections [ 13 ]. Due to its advantages of convenient drug delivery, rich vascularity of the nasal mucosa, high absorption rate, and targeted action, intranasal drug delivery has been used in the treatment of systemic diseases, such as the insulin treatment of diabetes mellitus [ 14 ]. Meanwhile, because intranasal drug delivery has the advantage of bypassing the blood-brain barrier, this route can also be used for targeted delivery to the brain [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, because intranasal drug delivery has the advantage of bypassing the blood-brain barrier, this route can also be used for targeted delivery to the brain [ 15 ]. However, intranasal administration has the disadvantage of having low stability due to the short residence time of the drug because of mucosal cilia clearance and drainage, enzymatic actions, and changes in nasal anatomy [ 14 ]. For some biomolecules, there may also be an increased risk of nasal injury [ 14 ], and long-term use may increase the risk of tumors [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary inhalation for disease treatment: Basic research and clinical translations

Wang,

Yang

et al. 2024

Materials Today Bio

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Intranasal delivery of biotechnology-based therapeutics

Cited by 7 publications

References 70 publications

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

Pulmonary inhalation for disease treatment: Basic research and clinical translations

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