Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection

Li, Yun; Xu, Yuling; Lai, Yunfeng; Liao, Shang-hui; Liu, Geoffrey; Xu, Pao

doi:10.1016/j.phymed.2017.08.014

Cited by 18 publications

(10 citation statements)

References 32 publications

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“… Not specified (Leaves) Inhibit virus replication completely Sadatrasul et al (2017) Eucalyptus camaldulensis Dehnh. 1,8-cineole (Leaves, Essential oil) Increase the production of influenza-specific serum immunoglobulin (Ig) G2a antibodies, stimulate mucosal secretive IgA (s-IgA) responses at the nasal cavity, improve the expression of respiratory tract intraepithelial lymphocytes (IELs) in the upper respiratory tract, and promote dendritic cell (DC) maturation and the expression of co-stimulatory molecules Li et al (2017) Eucalyptus camaldulensis Dehnh. Mentofin (Leaves, Essential oil) Inactivate Avian Influenza Virus (AIV) Barbour et al (2010) Eucalyptus globulus Labill.…”

Section: Resultsmentioning

confidence: 99%

Potential anti-influenza effective plants used in Turkish folk medicine: A review

Sargın

2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Due to the outbreaks such as SARS, bird flu and swine flu, which we frequently encounter in our century, we need fast solutions with no side effects today more than ever. Due to having vast ethnomedical experience and the richest flora (34% endemic) of Europe and the Middle East, Turkey has a high potential for research on this topic. Plants that locals have been using for centuries for the prevention and treatment of influenza can offer effective alternatives to combat this problem. In this context, 224 herbal taxa belonging to 45 families were identified among the selected 81 studies conducted in the seven regions of Turkey. However, only 35 (15.6%) of them were found to be subjected to worldwide in vitro and in vivo research conducted on anti-influenza activity. Quercetin and chlorogenic acid, the effectiveness of which has been proven many times in this context, have been recorded as the most common (7.1%) active ingredients among the other 56 active substances identified. Aim of the study This study has been carried out to reveal the inventory of plant species that have been used in flu treatment for centuries in Turkish folk medicine, which could be used in the treatment of flu or flu-like pandemics, such as COVID 19, that humanity has been suffering with, and also compare them with experimental studies in the literature. Materials and methods The investigation was conducted in two stages on the subject above by using electronic databases, such as Web of Science, Scopus, ScienceDirect, ProQuest, Medline, Cochrane Library, EBSCO, HighWire Press, PubMed and Google Scholar. The results of both scans are presented in separate tables, together with their regional comparative analysis. Results Data obtained on taxa are presented in a table, including anti-influenza mechanism of actions and the active substances. Rosa canina (58.7%) and Mentha x piperita (22.2%) were identified as the most common plants used in Turkey. Also, Sambucus nigra (11.6%) , Olea europaea (9.3%), Eucalyptus spp., Melissa officinalis, and Origanum vulgare (7.0%) emerged as the most investigated taxa. Conclusion This is the first nationwide ethnomedical screening work conducted on flu treatment with plants in Turkey. Thirty-nine plants have been confirmed in the recent experimental anti-influenza research, which strongly shows that these plants are a rich pharmacological source. Also, with 189 (84.4%) taxa, detections that have not been investigated yet, they are an essential resource for both national and international pharmacological researchers in terms of new natural medicine searches. Considering that the production of antimalarial drugs...

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Section: Resultsmentioning

confidence: 99%

Potential anti-influenza effective plants used in Turkish folk medicine: A review

Sargın

2021

Journal of Ethnopharmacology

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“…Eucalyptol has been shown to exert obvious anti‐inflammatory effects in several inflammatory conditions, including asthma, colitis, cigarette smoke‐induced acute lung inflammation, and influenza virus‐induced infection (Juergens, Stober, Schmidt‐Schilling, Kleuver, & Vetter, ; Kennedy‐Feitosa et al, ; Li et al, ; Santos et al, ). Eucalyptol also possesses analgesic effects in several pain conditions, including neuropathic orofacial pain and pain elicited by application of TRPA1 channel IL‐6, agonists to human skin (Melo Junior et al, ; Takaishi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis

Yin

Liu

Wang

et al. 2020

British J Pharmacology

119

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Background and Purpose: Gout arthritis, which is provoked by monosodium urate (MSU) crystal accumulation in the joint and periarticular tissues, induces severe pain and affects quality of life of the patients. Eucalyptol (1,8-cineol), the principal component in the essential oils of eucalyptus leaves, is known to possess anti-inflammatory and analgesic properties. We aimed to examine the therapeutic effects of eucalyptol on gout arthritis and related mechanisms. Experimental Approach: A mouse model of gout arthritis was established via MSU injection into the ankle joint. Ankle oedema, mechanical allodynia, neutrophil infiltration, oxidative stress, NLRP3 inflammasome, and TRPV1 expression were examined. Key Results: Eucalyptol attenuated MSU-induced mechanical allodynia and ankle oedema in dose-dependently, with effectiveness similar to indomethacin. Eucalyptol reduced inflammatory cell infiltrations in ankle tissues. Eucalyptol inhibited NLRP3 inflammasome activation and pro-inflammatory cytokine production induced by MSU in ankle tissues in vivo. Eucalyptol reduced oxidative stress induced by MSU in RAW264.7 cells in vitro as well as in ankle tissues in vivo, indicated by an increase in activities of antioxidant enzymes and reduction of ROS. Eucalyptol attenuated MSUinduced up-regulation of TRPV1 expression in ankle tissues and dorsal root ganglion neurons innervating the ankle. The in vivo effects of eucalyptol on ankle oedema, mechanical allodynia, NLRP3 inflammasome, IL-1β, and TRPV1 expression were mimicked by treating MSU-injected mice with antioxidants. Conclusion and Implications: Eucalyptol alleviates MSU-induced pain and inflammation via mechanisms possibly involving anti-oxidative effect. Eucalyptol and other antioxidants may represent promising therapeutic options for gout arthritis. Abbreviations: GSH-Px

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“…Twenty‐four hours postinfection (p.i.) cells were collected to detect the mRNA expression level of H1N1 M gene by qT‐PCR as previously described (Li et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…On day 5 postinfection, the mice were sacrificed to collect related samples, measure body weight, lung wet weight, and the degree of lung pathological change. The lung index was calculated as follows using the obtained values: Lung index = A / B × 100, where A is the lung weight, and B is the body weight (Li, Xu, et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Antiviral activity of puerarin as potent inhibitor of influenza virus neuraminidase

Wang

Zeng

et al. 2020

Phytotherapy Research

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Puerarin is a major isofiavone compound isolated from the root of Pueraria lobata. It was reported that puerarin had antioxidant, antiinflammatory, antitumor, cholesterol lowering, liver protective, and neuroprotective properties. However, few studies have explored the antiviral effect of puerarin and its target mechanism related to influenza virus. Here, the antiinfluenza activity of puerarin in vitro and in vivo and its mode of action on the potential inhibition of neuraminidase (NA) were investigated. Puerarin displayed an inhibitory effect on A/FM/1/1947(H1N1) (EC50 = 52.06 μM). An indirect immunofluorescence assay indicated that puerarin blocked the nuclear export of viral NP. The inhibition of NA activity confirmed that puerarin can block the release of newly formed virus particles from infected cells. Puerarin (100 and 200 mg/kg/d) exhibited effective antiviral activity in mice, conferring 50% and 70% protection from death against H1N1, reducing virus titers, and effectively alleviating inflammation in the lungs. The molecular docking results showed that puerarin had a strong binding affinity with NA from H1N1. The results of the molecular dynamics simulation revealed that puerarin had higher stable binding at the 150‐loop region of the NA protein. These results demonstrated that puerarin acts as a NA blocker to inhibit influenza A virus both in cellular and animal models. Thus, puerarin has potential utility for the treatment of the influenza virus infection.

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Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection

Cited by 18 publications

References 32 publications

Potential anti-influenza effective plants used in Turkish folk medicine: A review

Potential anti-influenza effective plants used in Turkish folk medicine: A review

Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis

Antiviral activity of puerarin as potent inhibitor of influenza virus neuraminidase

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