Intranasal Administration of Recombinant Mouse Interleukin‐12 Increases Inflammation and Demyelination in Chronic Experimental Autoimmune Neuritis in Lewis Rats

Pelidou, Sygkliti-Henrietta; Zou,; Deretzi,; Nennesmo,; Wei, Hsi Hsien; Mix,; Meide, van der; Zhu, Wanxue

doi:10.1046/j.1365-3083.2000.00636.x

Cited by 16 publications

(10 citation statements)

References 27 publications

(28 reference statements)

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“…IL-18 also induces the production of inflammatory cytokines IFN-γ and TNF-α [84], which probably contribute to the pathological process by activating macrophages and other cells or releasing secretions to attack the PNS tissue. Similar effects have also been shown for IL-12 [86] and administration of IL-12 exacerbates the symptoms of EAN [75]. Similar effects have also been shown for IL-12 [86] and administration of IL-12 exacerbates the symptoms of EAN [75].…”

Section: Role Of Cytokines In Gbssupporting

confidence: 78%

Pathogenesis of Guillain–Barré syndrome

Tsang¹,

Valdivieso-García²

2003

Expert Review of Anti-infective Therapy

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Guillain-Barre syndrome is a postinfectious disorder caused by an aberrant immune response to an infectious pathogen, resulting in an autoimmune disease. As with other autoimmune diseases of infectious nature, the intricate balance of the numerous factors involved in the immune response may determine the outcome of the interaction between the microbe and host. Recent studies focusing on the role of cytokines and its network of related mediators and receptors suggest that any imbalance may make a significant contribution to the outcome of the infectious disease process. Better understanding of the pathogenesis of Guillain-Barre syndrome may lead to the discovery of newer therapeutics and may also serve as a model for studying other autoimmune diseases.

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Section: Role Of Cytokines In Gbssupporting

confidence: 78%

Pathogenesis of Guillain–Barré syndrome

Tsang¹,

Valdivieso-García²

2003

Expert Review of Anti-infective Therapy

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“…Moreover, i.n. instillation of recombinant cytokines including IL-6 and IL-12 have been shown to affect the course of experimentally induced neurological disorders in rats (Kalueff et al, 2004;Pelidou et al, 2000). Although the mechanisms on how cytokines applied i.n.…”

Section: Discussionmentioning

confidence: 99%

Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

Tonelli

Holmes

Postolache

2007

Neuropsychopharmacol

116

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The association between activation of the immune system and mood disorders has been reported by several studies. However, the mechanisms by which the immune system affects mood are only partially understood. In the present study, we detected depressive-like behavior in a rat animal model which involves the induction of inflammation in the nasal cavities by intranasal (i.n.) instillation of bacterial lipopolysaccharides (LPS). Female rats showed depressive-like behavior as evidenced by the forced swim test after repeated i.n. administration of LPS. These responses were not paralleled by alterations in motor activity as measured by the open field test. In the same animals, corticosterone responses after the swimming sessions were the highest of all the groups evaluated. Real-time RT PCR was used to analyze the transcriptional regulation of the cytokines interleukin-1b, tumor necrosis factor-a, and interleukin-6 in several brain regions. Increased tumor necrosis factor-a was detected in the hippocampus and brainstem of female rats challenged with i.n. LPS. These results suggest that peripheral inflammation in the upper respiratory tract is an immune challenge capable of inducing depressive-like behavior, promoting exaggerated glucocorticoid responses to stress, and increasing cytokine transcription in the brain. These results further our understanding of the role that the immune system may play in the pathophysiology of depression.

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“…16 For in vivo administration, GM-CSF (1.0 g per 1 mL PBS) was injected intravenously into 6-week-old Wistar rats. Peripheral blood was assayed 24 hours after injection.…”

Section: Recombinant Cytokines/chemokinesmentioning

confidence: 99%

CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype

Baba

Ishizu

Iwasaki

et al. 2006

Blood

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We found a population of nonlymphoid cells expressing both CD4 and CD8 in peripheral blood mononuclear cells (PBMCs) of human T-cell leukemia virus type-I pX transgenic rats with autoimmune diseases. These cells, which showed a monocytic phenotype, were also found in wild-type rats, and their number increased by adjuvant-assisted immunization. GM-CSF increased the number of these double-positive (DP) monocytes in PBMCs. Consistent with the idea that DP monocytes differentiate into DP macrophages at sites of inflammation, we found infiltration of DP macrophages at the site of myosin-induced myocarditis in wild-type rats; these cells exhibited a T-helper 1 (Th1)-type cytokine/ chemokine profile and expressed high levels of Fas ligand, perforin, granzyme B, and NKR-P2 (rat orthologue of human NKG2D). Adoptive transfer of GFP-positive spleen cells confirmed hematogenous origin of DP macrophages. DP monocytes had a cytotoxic phenotype similar to DP macrophages, indicating that this phenotypic specialization occurred before entry into a tissue. In line with this, DP monocytes killed tumor cells in vitro. Combined evidence indicates that certain inflammatory stimuli that induce GM-CSF trigger the expansion of a population of DP monocytes with a cytotoxic phenotype and that these cells differentiate into macrophages at inflammatory sites. Interestingly, human PBMCs also contain DP

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Intranasal Administration of Recombinant Mouse Interleukin‐12 Increases Inflammation and Demyelination in Chronic Experimental Autoimmune Neuritis in Lewis Rats

Cited by 16 publications

References 27 publications

Pathogenesis of Guillain–Barré syndrome

Pathogenesis of Guillain–Barré syndrome

Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype

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