Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice

Youn, Ha-Na; Lee, Dong Hun; Lee, Yuna; Park, Jaekeun; Yuk, Seong‐Su; Yang, Si-Yong; Lee, Hyun-Jeong; Woo, Seo-Hyung; Kim, Hyoung-Moon; Lee, Joong‐Bok; Park, Seung‐Yong; Choi, In‐Soo; Song, Chang‐Seon

doi:10.1016/j.antiviral.2011.11.004

Cited by 105 publications

(92 citation statements)

References 26 publications

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“…Despite advances in medicine, RVI (such as the common cold or flu) continue to cause a considerable economic burden; fortunately, some probiotic strains have been studied for their positive effects on certain infectious diseases, and in the last 5 years, their use to prevent and treat RVI has significantly increased (11,12). There is thus a clear interest in the identification and characterization of new candidate strains with well-demonstrated probiotic properties against RVI.…”

Section: Discussionmentioning

confidence: 99%

“…Despite advances in medicine, common respiratory virus infections (RVI) such as the common cold or flu continue to cause a considerable economic burden; fortunately, some probiotic strains have been studied for their positive effects on these virus infections (11,12). Indeed, products containing probiotics have been shown to have an immunomodulatory effect and a protective effect against RVI in both mice and humans (13)(14)(15).…”

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confidence: 99%

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Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Kechaou

Chain

Gratadoux

et al. 2013

Appl Environ Microbiol

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In this study, we developed a large-scale screening of bacterial strains in order to identify novel candidate probiotics with immunomodulatory properties. For this, 158 strains, including a majority of lactic acid bacteria (LAB), were screened by two different cellular models: tumor necrosis factor alpha (TNF-␣)-activated HT-29 cells and peripheral blood mononuclear cells (PBMCs). Different strains responsive to both models (pro-and anti-inflammatory strains) were selected, and their protective effects were tested in vivo in a murine model of influenza virus infection. Daily intragastric administrations during 10 days before and 10 days after viral challenge (100 PFU of influenza virus H1N1 strain A Puerto Rico/8/1934 [A/PR8/34]/mouse) of Lactobacillus plantarum CNRZ1997, one potentially proinflammatory probiotic strain, led to a significant improvement in mouse health by reducing weight loss, alleviating clinical symptoms, and inhibiting significantly virus proliferation in lungs. In conclusion, in this study, we have combined two cellular models to allow the screening of a large number of LAB for their immunomodulatory properties. Moreover, we identified a novel candidate probiotic strain, L. plantarum CNRZ1997, active against influenza virus infection in mice.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Kechaou

Chain

Gratadoux

et al. 2013

Appl Environ Microbiol

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“…Fermented foods and dairy products have been known contain a variety of probiotic LAB strains (Hanniffy et al, 2004;Drouault and Corthier, 2001;Parvez et al, 2006). It was demonstrated that LAB probiotic strains were able to protect against infectious diseases (Corr et al, 2007;Youn et al, 2012), and display anti-allergic effects on immune diseases in mice (Fujiwara et al, 2004;Nagai et al, 2011), chicken (Seo et al, 2012) and humans (Nagao et al, 2000;Ishida et al, 2005). However, it remains unknown whether treatments with LAB can confer improved protection.…”

Section: Introductionmentioning

confidence: 99%

Antiviral mode of action of <i>Lactobacillus plantarum</i> YML009 on Influenza virus H1N1

Rather

Choi

Bajpai

et al. 2015

Bangladesh J Pharmacol

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Isolation and identification of lactobacillus plantarum YML009LAB were isolated by homogenizing different types of Kimchi samples and then filtering the homogenate through a sieve (100 mesh). An appropriate volume of the filtered homogenate was diluted by decimal dilution and spread onto MRS agar (Difco laboratories, USA), followed by incubation at 37°C for 24 hours. AbstractThe development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe "nutraceutical" in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009.Article Info

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“…Previous studies have suggested that live probiotics are the most effective for modulating the immune response of the host [60][61][62]. However, extracts of probiotics have been demonstrated to have similar or even more effective activity for stimulating and modulating immune response compared to live probiotics.…”

Section: ⅲ Probiotic Extracts Including Lta and Skin Healthmentioning

confidence: 95%

Probiotic Lactic Acid Bacteria and Skin Health

Jeong

Lee

Chung

2015

Critical Reviews in Food Science and Nutrition

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Human skin is the first defense barrier against the external environment, especially microbial pathogens and physical stimulation. Many studies on skin health with Lactic acid bacteria (LAB) have been published for many years, including prevention of skin disease and improvement of skin conditions. LAB, a major group of gram-positive bacteria, are known to be beneficial to human health by acting as probiotics. Recent studies have shown that LAB and their extracts have beneficial effects on maintenance and improvement of skin health. Oral administration of Lactobacillus delbrueckii inhibits the development of atopic disease. In addition, LAB and LAB extracts are known to have beneficial effects on intestinal diseases, with Lactobacillus plantarum having been shown to attenuate IL-10 deficient colitis. In addition to intestinal health, L. plantarum also has beneficial effects on skin. pLTA, which is lipoteichoic acid isolated from L. plantarum, has anti-photoaging effects on human skin cells by regulating the expression matrix meralloprotionase-1 (MMP-1) expression. While several studies have proposed a relationship between diseases of the skin and small intestines, there are currently no published reviews of the effects of LAB for skin health through regulation of intestinal conditions and the immune system. In this review, we discuss recent findings on the effects of LAB on skin health and its potential applications in beauty foods.

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Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice

Cited by 105 publications

References 26 publications

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Antiviral mode of action of <i>Lactobacillus plantarum</i> YML009 on Influenza virus H1N1

Probiotic Lactic Acid Bacteria and Skin Health

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