Intranasal administration of gold nanoparticles designed to target the central nervous system: Fabrication and comparison between nanospheres and nanoprisms

Gallardo-Toledo, Eduardo; Tapia-Arellano, Andreas; Célis, Freddy; Sinai, Tomer; Campos, Marcelo; Kogan, Marcelo J.; Sintov, Amnon

doi:10.1016/j.ijpharm.2020.119957

Cited by 22 publications

(14 citation statements)

References 80 publications

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“…T7 peptide (Ac-Cys-His-Ala-Ile-Tyr-Pro-Arg-CONH 2 ) in combination with gold-iron oxide NPs (Au-Fe 2 O 3 NPs) showed greater accumulation in the brain than unmodified nanosystem. The same result was obtained when using a modification of D1 peptide (Gln-Ser-His-Tyr-Arg-His-Ile-Ser-Pro-Ala-Gln-Val) of gold NPs (AuNPs), even though comparison with the unmodified carrier was not reported [158].…”

Section: Nanoparticles Functionalized With Targeting Ligandssupporting

confidence: 58%

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Borrajo

Alonso

2021

Drug Deliv. and Transl. Res.

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There is a growing number of biomolecules, including peptides, proteins, monoclonal antibodies and RNA, that could be potentially used for the treatment of central nervous system (CNS) diseases. However, the realization of their potential is being hampered by the extraordinary difficulties these complex biomolecules have to reach the brain in therapeutically meaningful amounts. Nose-to-brain (N-to-B) delivery is now being investigated as a potential option for the direct transport of biomolecules from the nasal cavity to different brain areas. Here, we discuss how different technological approaches enhance this N-to-B transport, with emphasis on those that have shown a potential for clinical translation. We also analyse how the physicochemical properties of nanocarriers and their modification with cell-penetrating peptides (CPPs) and targeting ligands affect their efficacy as N-to-B carriers for biomolecules. Graphical abstract

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Section: Nanoparticles Functionalized With Targeting Ligandssupporting

confidence: 58%

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Borrajo

Alonso

2021

Drug Deliv. and Transl. Res.

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“…Gelatin nanoparticles (GNPs) have been used as intranasal delivery carriers for osteopontin (OPN) in the treatment of ischemic stroke (Joachim et al, 2014). Intranasal administration was the process by which substances in the nasal cavity passed through the olfactory mucosa, following the olfactory nerve into the CNS (Gallardo-Toledo et al, 2020). It quickly and noninvasively delivers drugs to ischemic sites without crossing the BBB.…”

Section: Natural Polymersmentioning

confidence: 99%

Advances in the research of nano delivery systems in ischemic stroke

Wang²,

Jin³

et al. 2022

Front. Bioeng. Biotechnol.

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Ischemic stroke is the most common type of cerebrovascular disease with high disability rate and mortality. The blood-brain barrier (BBB) protects the homeostasis of the brain’s microenvironment and impedes the penetration of 98% of drugs. Therefore, effective treatment requires the better drug transport across membranes and increased drug distribution. Nanoparticles are a good choice for drugs to cross BBB. The main pathways of nano delivery systems through BBB include passive diffusion, adsorption-mediated endocytosis, receptor-mediated transport, carrier-mediated transport, etc. At present, the materials used in brain-targeted delivery can be divided into natural polymer, synthetic polymers, inorganic materials and phospholipid. In this review, we first introduced several ways of nano delivery systems crossing the BBB, and then summarized their applications in ischemic stroke. Based on their potential and challenges in the treatment of ischemic stroke, new ideas and prospects are proposed for designing feasible and effective nano delivery systems.

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“…Gallardo-Toledo et al reported the use of gold nanospheres (GNS) (47 nm) and nanoprisms (GNPr) (78 nm) with similar surface areas to assess their transport to the brain after IN administration. The authors used PEG and D1 peptide (GNS-D1 and GNPr-D1) as functionalizing agents [97]. The results exposed that even though both NP had comparable surface area, size, and zeta potential, their different shapes considerably influenced their translocation to the brain from the nasal cavity, being more substantial for nanospheres (GNS-D1) (Fig.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

Formica

Real

Picchio

et al. 2022

Applied Materials Today

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Intranasal administration of gold nanoparticles designed to target the central nervous system: Fabrication and comparison between nanospheres and nanoprisms

Cited by 22 publications

References 80 publications

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Advances in the research of nano delivery systems in ischemic stroke

On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

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