Intramedullary spinal cord metastasis from malignant melanoma: a case report of a central nervous system secondary lesion occurred 15 years after the primary skin lesion resection

Śniegocki, Maciej; Nowacka, Agnieszka; Smuczyński, Wojciech; Woźniak, Kamila

doi:10.5114/ada.2018.72760

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Untreated spinal metastatic melanoma develops rapidly and the average survival time is 6-12 months [4]. Such melanomas are resistant to radiotherapy; surgical resection is indicated despite the high risk of iatrogenic neurological [9]. However, the prognosis of MUP is better than that of metastatic melanoma, with an overall 5-year survival rate of 28% [3].…”

Section: Discussionmentioning

confidence: 99%

A Primary Sacral Melanoma of Unknown Origin: A Case Report

Bozkurt¹,

Yasar²,

Uslu³

et al. 2022

Oncologie

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Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4-5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant melanoma. We discuss the diagnosis, surgical intervention, and postoperative follow-up, which may assist clinicians. Although metastatic malignant melanoma is usually fatal, primary extracutaneous melanoma of the spine may respond well to surgery and adjuvant radiotherapy.

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Section: Discussionmentioning

confidence: 99%

A Primary Sacral Melanoma of Unknown Origin: A Case Report

Bozkurt¹,

Yasar²,

Uslu³

et al. 2022

Oncologie

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“…Patients expected to respond well to therapeutic intervention are considered candidates for surgical treatment, which can improve the overall survival and neurological functions ( 2 ). A few patients with ISCMs of malignant melanoma undergo surgical resection because melanoma tends to be highly resistant to radiation ( 3 ). Therefore, the dose of radiation for melanoma is often 4 Gy or more/fraction.…”

Section: Discussionmentioning

confidence: 99%

Intramedullary spinal cord metastasis of malignant melanoma:Two cases with rim signs in contrast‑enhanced magnetic resonance imaging: A case report

Mizuta¹,

Namikawa²,

Nakama³

et al. 2021

Mol Clin Oncol

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Spinal cord metastasis of malignant melanoma is mostly caused by the invasion of the spinal cord by malignant melanoma. However, direct metastasis in the spinal cord is rare and difficult to diagnose accurately. A few diagnostically valuable findings of intramedullary spinal cord metastases (ISCMs) have been published. However, a highly specific finding of ISCMs of all carcinomas is the 'rim sign', which signifies the enhancement of the edge-dominant effect of the lesion in contrast-enhanced MRI. The objective of this case series was to examine the ratio of ISCMs of malignant melanoma with an indication of rim signs in contrast-enhanced MRI. The present report describes two cases of ISCMs of malignant melanoma in which the rim sign in contrast-enhanced MRI was useful for diagnosis.

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