Intramedullary spinal cord metastasis and multiple brain metastases from urothelial carcinoma

Abdulazim, Amr; Backhaus, Manuel; Stienen, Martin N.; Citak, Mustafa; Brokinkel, Benjamin; Horch, C.

doi:10.1016/j.jocn.2011.01.039

Cited by 9 publications

(13 citation statements)

References 13 publications

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“…Sudden onset of neurological deficit and rapid progression are the most consistent characteristics of ISCM and this is helpful in distinguishing it from the slow growing primary spinal intramedullary tumours [8,13]. The distribution of the weakness is asymmetric in most patients with ISCM, as it was in our patient and in one of the two other cases [8,12]. Paresthesia is less frequent as an initial symptom.…”

Section: Discussionsupporting

confidence: 57%

“…In 50-59% of cases there are concurrent brain metastases [10,12]. However, unlike the other two cases, no brain metastasis was determined in our patient [3,12].…”

Section: Discussioncontrasting

confidence: 53%

“…Paresthesia is less frequent as an initial symptom. There was also no sensory deficit in our patient, but both of the other two ISCM of bladder cancer cases had sensory deficits [12,3]. Dysfunction of bowel and bladder are unusual early manifestations of intramedullary spinal cord metastasis.…”

Section: Discussionmentioning

confidence: 46%

“…However, there is still no technique that is capable of distinguishing ISCM from primary spinal cord neoplasm or other non-neoplastic lesions [11]. MRI with gadolinium was performed in our patient and the other two cases to determine the ISCM lesion [12,3]. Complete brain and spine imaging, preferably with MRI, as performed in our patient, is important before treatment decisions.…”

Section: Discussionmentioning

confidence: 87%

“…Most of the intramedullary metastases occur primarily from lung cancer while the others originate from breast cancer, malign melanoma, ovarian tumour, Hodgkin's disease, colorectal carcinoma, thyroid carcinoma and renal cell carcinoma [1,3,[5][6][7][8][9][10][11]. There is a long list of primary tumours that metastasize to the spinal cord, but ISCM of bladder cancer is documented in only two case reports [3,12]. To our knowledge, this report will be documenting the third case of intramedullary metastasis originating from bladder cancer, however it is the only one presenting without any additional metastases.…”

Section: Introductionmentioning

confidence: 99%

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Intramedullary Spinal Cord Metastasis of Bladder Carcinoma: A Case Report

AlÄ±cÄ±kuÅ¹,

DaÄdelen²,

Görken³

et al. 2014

J Palliat Care Med

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Objective: Intramedullary spinal cord metastasis (ISCM) is a rare type of central nervous system involvement of cancer and there are only two cases of bladder cancer's ISCM in literature. This is the third one presenting with an ISCM of bladder cancer, but is the only one presenting without any additional metastases. Clinical information:A 76-year-old man had radical radiotherapy and adjuvant chemotherapy for bladder cancer four months ago, and was with no evidence of disease. He suffered from sudden severe pain on his neck and progressive weakness of the extremities. The deep tendon reflexes were hypoactive in upper extremities and absent in lower extremities. There was no other neurological deficit. Magnetic resonance imaging scan revealed an enhancing intramedullary lesion at the level of third cervical vertebra with peritumoural edema. Immediately, his corticotherapy was started and subtotal mass resection with laminectomy was performed. The pathological examination showed a metastatic carcinoma of the bladder cancer. Then, he had fractionated external beam radiotherapy to the cervical region with corticotherapy. After two months with a better neurological state, his clinical state worsened and he died of a cardiopulmonary arrest. Conclusion:There is no consensus on the best therapy, however, it can be well palliated with combination therapy of surgery, irradiation and corticosteroids.

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Section: Discussionsupporting

confidence: 57%

“…In 50-59% of cases there are concurrent brain metastases [10,12]. However, unlike the other two cases, no brain metastasis was determined in our patient [3,12].…”

Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 46%