Intramedullary spinal cord germinoma expresses the protooncogene c-kit

Watanabe, Akira; Horikoshi, Toru; Naganuma, Hirofumi; Satoh, Eiji; Nukui, Hideaki

doi:10.1007/s00701-004-0450-x

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Among the previous reports of primary spinal cord germinoma, we summarized cases that required >1 year from the onset of symptoms for an accurate diagnosis (Table 1). [11][12][13][14][15][16][17][18][19] The tumor is commonly located at the thoracic level, and patients usually develop lower-extremity symptoms. Two case reports (Cases 3 and 8) showed no abnormal findings on the initial MRI after onset, but there were abnormal findings on the follow-up MRI.…”

Section: Discussionmentioning

confidence: 99%

Occult Germinoma of the Intramedullary Spinal Cord: A Case Report

HOSHIMARU

TAKAGI

Tsuji

et al. 2023

NMC Case Report Journal

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Primary germ cell tumors of the central nervous system (CNS) typically occur in the neurohypophysis, hypothalamus, or pineal gland and rarely in the spinal cord. We report a case of a spinal intramedullary tumor, which was first detected on magnetic resonance imaging (MRI) 41 months after the initial symptoms, with a verified pathological diagnosis of germinoma. The initial symptom was an abnormal sensation in the left plantar region that gradually worsened, resulting in severe sensory disturbance, difficulty in standing, and even bladder rectal disturbance. Repeated MRI after the onset failed to provide an imaging diagnosis. The MRI was performed 41 months after the onset and revealed a previously undiagnosed, contrast-enhancing spinal intramedullary neoplastic lesion at the Th11-12 level. Gross total resection of the tumor was successfully performed, and the pathology confirmed the diagnosis of pure germinoma. Postoperative chemotherapy, followed by local radiation, was successfully administered. Among primary germinomas of the CNS, occult germinoma that lacks imaging findings suggestive of tumors in the early stages of onset and becomes apparent over time is often reported as a primary neurohypophyseal germinoma, particularly in adolescents presenting with diabetes insipidus. In the present case, the lesion appeared to correspond to a primary occult germinoma of the intramedullary spinal cord.

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Section: Discussionmentioning

confidence: 99%

Occult Germinoma of the Intramedullary Spinal Cord: A Case Report

HOSHIMARU

TAKAGI

Tsuji

et al. 2023

NMC Case Report Journal

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“…13,17) In our case, combined chemotherapy using three cycles of carboplatin and etoposide was performed with whole spine radiation (24.5 Gy per 14 fractions), the same protocol used for pure intracranial germinomas. 14) Although vincristine, 9) bleomycin, 9) or methotrexate 21) have been used for spinal germinoma, the combination of carboplatin, etoposide, 8,20,25) or ifosfamide 2) has usually been administered in more recent cases. Intraspinal germinomas have immunohistochemical similarities to intracranial germinomas, including expression of PLAP and c-kit.…”

Section: Discussionmentioning

confidence: 99%

“…3) Conversely, primary intramedullary spinal cord germinomas are rarely reported, but many of the reported cases occur in Asian patients. 2,3,5-11, [16][17][18][19][20][21][22][23][24][25][26] Spinal germinomas are difficult to identify based on the neuroimaging findings because of the similarity with spinal astrocytomas and ependymomas. However, correct diagnosis is important, because patients with germinomas can be treated with chemotherapy and radiotherapy, in contrast to patients with astrocytomas.…”

Section: Introductionmentioning

confidence: 99%

Primary Intramedullary Spinal Cord Germinoma -Case Report-

Kinoshita

Akatsuka

Ohtake

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Fig. 1 Magnetic resonance images on admission showing two spinal tumors, a fusiform, heterogeneously enhanced, intramedullary mass at the T9-T11 levels, and a rod-shaped slightly enhanced mass at the L2-L3 levels of the cauda equina, both appearing hyperintense on T 2 -weighted imaging (left), with enhancement by gadolinium (right). AbstractA 21-year-old woman presented with an intramedullary spinal cord germinoma and a history of gait disturbance and elimination disorder. Magnetic resonance (MR) imaging demonstrated two isolated lesions, one located within the medulla between T9 and T11, and another at the cauda equina (L2 to L3 levels). After partial reduction of the intramedullary mass, histological findings revealed that the tumor was typical germinoma. Further MR imaging revealed no evidence of intracranial germinoma. Combined chemotherapy (carboplatin and etoposide) and whole spine radiation were performed. Follow-up MR imaging showed that the enhanced mass at the L2-L3 levels had disappeared. No recurrence of the tumor has been detected 3 years after the operation, and no dissemination into the cranial area was detected. Cisplatin and etoposide chemotherapy combined with radiotherapy is recommended for primary spinal germinoma, and is effective for inhibition of both tumor dissemination and recurrence.

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“…There were 13 male and 10 female patients with ages ranging from 5 to 43 years (mean age: 25 years). The tumors predisposed to arise from the lower thoracic and lumbar spinal region 1–23 . Only one case occurred in the middle portion of cervical spinal cord 15 .…”

Section: Discussionmentioning

confidence: 99%

MR Imaging of Primary Spinal Germinoma: A Case Report and Review of the Literature

Chen

Chou

et al. 2009

Journal of Neuroimaging

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Germinomas in the central nervous system (CNS) are uncommon tumors and occur usually in the pineal or suprasellar regions. Primary spinal germinoma is extremely rare. Here we reported a rare case of an extramedullary germinoma in a young adult who presented with progressive paraparesis and retention of stool and urine. The MR image features with their differential diagnoses were discussed along with literature review of all previously reported 22 cases.

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Intramedullary spinal cord germinoma expresses the protooncogene c-kit

Cited by 11 publications

References 23 publications

Occult Germinoma of the Intramedullary Spinal Cord: A Case Report

Occult Germinoma of the Intramedullary Spinal Cord: A Case Report

Primary Intramedullary Spinal Cord Germinoma -Case Report-

MR Imaging of Primary Spinal Germinoma: A Case Report and Review of the Literature

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