Intramedullary metastases due to non microcytic lung carcinoma

Escalante, Sonia; Ortiz, M.; Ponce, Carmen Guillén; Lescure, Álvaro Rodríguez; Plazas, Javier Gallego; Mena, Alfredo Carrato

doi:10.1007/s12094-006-0203-9

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2007

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“…One patient (case 1) presented a low performance status and one patient (case 6) with diagnosis of SCLC was considered for chemotherapy. Chemotherapy has also been tested as single treatment in individual patients with ISCM of NSCLC, although without therapeutic success [20].…”

Section: Discussionmentioning

confidence: 99%

Clinical outcome in patients with intramedullary spinal cord metastases from lung cancer

et al. 2007

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Intramedullary spinal cord metastases (ISCM) are uncommon and present with rapidly progressing neurological deficits. The objective of this study was to determine the rate, duration of neurological response and survival after radiation therapy. We have retrospectively reviewed the clinical outcome of six cases with a diagnosis of ISCM from primary lung cancer, non-small cell (NSCLC) (n=3) and small cell (SCLC) (n=3). Total radiation dose ranged from 27 Gy/5 fr to 40 Gy/20 fr. Ambulation was preserved in 3 patients and partially recovered in one. Five out of the six patients (83%) showed improvement in neurological signs/symptoms with a mean duration of 17.2 days (max: 40 days; min: 6 days). Median survival time was 5 months (confidence interval (CI) 95%: 0-12) for NSCLC and 5 months (CI 95%: 4-6) for SCLC. Although radiation response rate is high, the interval free of neurological progression is very short. A therapeutic approach should be considered for each individual.

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Section: Discussionmentioning

confidence: 99%