Intramedial Renal Arterial Nerves

Knight, David S.; Bazer, Gary T.; Feigen, Larry P.; Kadowitz, P. J.

doi:10.1159/000158353

J Vasc Res

1981

DOI: 10.1159/000158353

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Intramedial Renal Arterial Nerves

David S. Knight

Gary T. Bazer

Larry P. Feigen

et al.

Abstract: In this study, 5-hydroxydopamine was used to help differentiate adrenergic and nonadrenergic nerve terminals in canine renal arteries. There were both adrenergic and non-adrenergic varicosities in the adventitia near the outer surface of the media. The adrenergic varicosities had accumulated 5-hydroxydopamine, were more numerous than the nonadrenergic varicosities, and were found in the media in close relation to smooth muscle cells.

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1992

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Cited by 2 publications

References 10 publications

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Innervation of the renal vasculature of the toad (Bufo marinus)

Morris

Gibbins

1983

Cell Tissue Res.

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The innervation of the dorsal aorta and renal vasculature in the toad (Bufo marinus) has been studied with both fluorescence and ultrastructural histochemistry. The innervation consists primarily of a dense plexus of adrenergic nerves associated with all levels of the preglomerular vasculature. Non-adrenergic nerves are occasionally found in the renal artery, and even more rarely near the afferent arterioles. Many of the adrenergic nerve profiles in the dorsal aorta and renal vasculature are distinguished by high proportions of chromaffin-negative, large, filled vesicles. Close neuromuscular contacts are common in both the renal arteries and afferent arterioles. Possibly every smooth muscle cell in the afferent arterioles is multiply innervated. The glomerular capillaries and peritubular vessels are not innervated, and only 3-5% of efferent arterioles are accompanied by single adrenergic nerve fibres. Thus, nervous control of glomerular blood flow must be exerted primarily by adrenergic nerves acting on the preglomerular vasculature. The adrenergic innervation of the renal portal veins and efferent renal veins may play a role in regulating peritubular blood flow. In addition, glomerular and postglomerular control of renal blood flow could be achieved by circulating agents acting via contractile elements in the glomerular mesangial cells, and in the endothelial cells and pericytes of the efferent arterioles. Some adrenergic nerve profiles near afferent arterioles are as close as 70 nm to distal tubule cells, indicating that tubular function may be directly controlled by adrenergic nerves.

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Innervation of the renal vasculature of the toad (Bufo marinus)

Morris

Gibbins

1983

Cell Tissue Res.

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Anatomy of the renal innervation: intrarenal aspects and ganglia of origin

Barajas

Liu²,

Powers³

1992

Can. J. Physiol. Pharmacol.

180

112

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The intrinsic innervation of the kidney is described based on studies using ultrastructural, fluorescent, immunocytochemical, and autoradiographic techniques. The efferent sympathetic innervation reaches all the segments of the renal vasculature and to a much lesser extent the tubular nephron. The afferent renal nerves are localized predominantly in the pelvic region, the major vessels, and the corticomedullary connective tissue. The pathways of the renal innervation to the corresponding ganglia, as reported from observations resulting from the combination of axonal transport labeling and immunocytochemical methods, are presented. In the rat the ganglia of origin of the sympathetic efferent innervation include T13-L1 ipsilateral and contralateral paravertebral ganglia and the prevertebral superior mesenteric and celiac ganglia. The sensory afferent innervation presents a different segmental distribution of the dorsal root ganglia for the right and left kidney. For the left kidney, the corresponding ganglia extend from T8 to L2 with the greatest numbers in T12 and T13. For the right kidney, ganglia as high as T6 and as low as L2 harbor neurons innervating the kidney. Current knowledge of the anatomical bases of the function of the renal nerves is discussed.

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Intramedial Renal Arterial Nerves

Cited by 2 publications

References 10 publications

Innervation of the renal vasculature of the toad (Bufo marinus)

Innervation of the renal vasculature of the toad (Bufo marinus)

Anatomy of the renal innervation: intrarenal aspects and ganglia of origin

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