Intramammary Nodal Metastasis from Ovarian Cancer: A Case Report

Hamdy, Omar; Shokeir, Farida A; Saleh, Gehad A.; Zaki, Marwa Ma

doi:10.5152/ejbh.2019.4712

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Ovarian cancer is one of the most common gynecologic malignancy in the world [1]. However, it generally presents at an advanced stage which is one of the main factors contributing to the high death to incidence rate [2].…”

Section: Introductionmentioning

confidence: 99%

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

Deng

et al. 2020

J Ovarian Res

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Objective: circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is to explore the role of circRNA-UBAP2 in ovarian cancer and its mechanism. Results: circRNA-UBAP2 was upregulated in ovarian cancer tissues and cell lines. Knockdown of circRNA-UBAP2 inhibited cell proliferation and promoted cell apoptosis, but circRNA-UBAP2 overexpressed got opposite results. In addition, circRNA-UBAP2 targeted miR-382-5p and downregulated its expression, PRPF8 was a target gene of miR-382-5p. Furthemore, circRNA-UBAP2/miR-382-5p/PRPF8 axis affected the proliferation, apoptosis and cell cycle of ovarian cancer through the mechanism of competing endogenous RNAs (ceRNA). Conclusion: circRNA-UBAP2 acted as a ceRNA to sponged miR-382-5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells.

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Section: Introductionmentioning

confidence: 99%

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

Deng

et al. 2020

J Ovarian Res

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“…The rst follows an anterior pathway to the prepericardial nodes then the subclavian lymph trunk ending eventually the axillary lymph nodes, while the other one is posteriorly through inferior diaphragmatic nodes to super cial umbilical lymphatics that end in cisterna chyli that is continuous into the thoracic duct which ends at the junction between the left subclavian and internal jugular veins (9). It should be mentioned that thorough clinical, radiological, and pathological interpretation is crucial to differentiate these patients from primary breast carcinomas with ovarian metastasis (10). In our study, axillary and intramammary nodal metastasis was reported in 7 patients (14.6%), 3 patients presented as a recurrent event through their disease course.…”

Section: Discussionmentioning

confidence: 99%

Behaviour and Prognosis of Ovarian Cancer With Rare Metastatic Sites

Zuhdy

Alghandour

Hamdy

et al. 2021

Preprint

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Purpose: Ovarian cancer is the commonest gynecologic malignancy in Egypt. Although metastasis from ovarian cancer is common, there are still sites with rarely reported deposits as non-regional nodes, bone, and brain. Methods: This is a chorort study were we retrospectively a group of patients over 7 years period recruited from the data system of a cancer centre. All the recruited patients suffered a rare distant metastasis from ovarian cancer. Results: Nearly half of the patients already had metastasis at the time of the initial presentation, while the rest developed during the disease course. Debulking was feasible in nearly half of the patients with long overall and progression-free survival. Tumours with non-regional nodal metastases tend to have excellent survival. Conclusion: we recommend offering these patients optimal debulking and considering those with a non-regional nodal spread as having a curable disease.

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“…BOM is usually associated with the serous papillary adenocarcinoma subtype, an aggressive and advanced disease, and a poor prognosis [ 9 – 19 ].As BMs usually develop out of the mammary ductal system, they clinically present as round, rapid growing, painless, and mobile lesions without any cutaneous alteration [ 4 – 8 ].Radiologically, BMs typically appear as regular lesions without skin infiltration or peri-tumoral desmoplastic reaction [ 4 – 8 ]. Microcalcifications are rare and usually associated with psammoma bodies in ovarian cancer patients [ 4 – 9 ].…”

Section: Discussionmentioning

confidence: 99%