Intramammary metastases: Comparison of mammographic and ultrasound features

Abbas, Jasmin; Wienke, Andreas; Spielmann, R. P.; Bach, Andreas; Surov, Alexey

doi:10.1016/j.ejrad.2013.04.032

Cited by 25 publications

(25 citation statements)

References 14 publications

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“…In rare occurrence, much further metastatic sites of the ovarian carcinoma have also been reported such as in the brain (Koul et al, 2001; Sekine et al, 2013; Longo et al, 2014), breast (Dursun et al, 2009; Karam et al, 2009; Abbas et al, 2013; Tempfer et al, 2016), lung (Carbonari et al, 2015; Upadhyay et al, 2015), pancreas (Nakamura et al, 2016), and gastrointestinal track (Zhou and Miao, 2012), thus suggesting an alternative route of metastasis in EOC. Previous studies have reported that the presence of circulating tumor cells (CTCs) in the blood circulation of the ovarian cancer patients (Pecot et al, 2011; Phillips et al, 2012), which implies that ovarian tumor cells may also follow ‘hematogenous’ route of metastasis through blood stream.…”

Section: Mir-200c-mediated Metastasismentioning

confidence: 99%

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

2016

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Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed.

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Section: Mir-200c-mediated Metastasismentioning

confidence: 99%

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

2016

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“…For instance, the largest lesions occurred in rhabdomyosarcomas, followed by hepatocellular carcinomas and squamous cell carcinomas of the head and neck region. The smallest lesions occurred in thyroid gland carcinomas [13]. Most breast metastases showed circumscribed margins, while metastases from rhabdomyosarcomas were microlobulated [13].…”

Section: Discussionmentioning

confidence: 99%

“…The smallest lesions occurred in thyroid gland carcinomas [13]. Most breast metastases showed circumscribed margins, while metastases from rhabdomyosarcomas were microlobulated [13]. On ultrasound, breast lesions in lung cancers were usually inhomogeneously hypoechoic with circumscribed margins and demonstrated posterior shadowing in almost 50% of the cases.…”

Section: Discussionmentioning

confidence: 99%

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Solitary breast metastasis from myxoid liposarcoma

et al. 2014

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BackgroundMetastasis to the breast from nonmammary malignancies is rare, and mostly involves patients in a pre-terminal condition with systemic metastases outside the breast. Lymphoma and leukemia, melanoma, and lung carcinoma are the most common primary malignancies to cause breast metastasis; metastasis of soft tissue sarcoma to the breast is very rare. Here, we report a case of primary lower-extremity myxoid liposarcoma with the development of a solitary metastasis to the breast. To the best of our knowledge, no isolated case reports of solitary breast metastasis by myxoid liposarcoma have been previously reported in the English-language literature.Case presentationThe patient, a 66-year-old woman, had been previously diagnosed with myxoid liposarcoma of the right thigh. At 21 months after complete surgical resection of the primary tumor with negative margins, a palpable tumor was identified in the patient’s left breast. Needle biopsy revealed the presence of metastatic liposarcoma; positron emission tomography/computed tomography examination confirmed the metastasis as solitary, and no local recurrence of the primary tumor was identified. The patient underwent lumpectomy with negative margins and did not provide consent for adjuvant chemotherapy. As with the biopsy specimen and the total cleavage specimen, myxoid liposarcoma with metastasis to the breast was diagnosed. No recurrence or new metastases were observed five years after resection of the metastatic breast lesion.ConclusionsWe have presented an extremely rare case of a solitary metastatic breast tumor arising from myxoid liposarcoma of the lower limbs. There is no standard treatment for the management of solitary breast metastasis from myxoid liposarcoma. Therefore, treatment should be guided by consideration of an individual patient’s overall condition.

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“…Intramammary metastases from solid neoplasms are rare, accounting about 0.33%-6.3% of breasts malignancies, and arise most frequently from melanomas, sarcomas, lung cancer ovarian tumors, and renal carcinomas [1] , [2] .…”

Section: Introductionmentioning

confidence: 99%

Breast metastasis from ovarian cancer: A case report

Latronico

Faggian

Nicosia

et al. 2018

Radiology Case Reports

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Breast metastasis from ovarian cancer is a rare event, with vary clinical and imaging presentations, depends on the form of dissemination of the disease and may mimic primary benign and malignant lesions.Confirmation of the diagnosis is of pivotal importance to choice an adequate therapeutic planning, allowing to avoid unnecessary surgeries and to provide appropriate systemic therapy. In this manuscript, we present a case of breast metastasis from ovarian cancer. The patient presented to our Institute with a localized, palpable mass in the upper outer quadrant of the right breast. Mammography and breast sonography showed a singular, round, and homogenous mass with regular borders. No suspicious axillary node was observed. Lesion biopsy revealed the presence of epithelial malignant tumor cells, compatible with a tube-ovarian serous histotype. So, although it could be rare, secondary malignant neoplasm should be considered in the differential diagnosis of breast lesions in patients with a personal history of ovarian cancer.

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Intramammary metastases: Comparison of mammographic and ultrasound features

Cited by 25 publications

References 14 publications

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

Solitary breast metastasis from myxoid liposarcoma

Breast metastasis from ovarian cancer: A case report

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