Intralymphatic CD30+ T‐cell proliferation during DRESS: a mimic of intravascular lymphoma

Abstract

We report the first case of benign atypical intralymphatic CD30+ T-cell proliferation associated with DRESS. Diagnostic clues include immunohistochemistry, absence of TcR clonal rearrangement, and anatomo-clinical correlation.

Benign atypical intralymphatic CD30+ lymphoid proliferation with activated regulatory T‐cell phenotype in the oral cavity

“…The associated skin lesions were molluscum contagiosum, hemangioma, pyogenic granuloma, lichen sclerosus, hidradenitis suppurativa and prurigo nodule, as well as endometrial polyp and trauma . Recently, a case associated with drug rash with eosinophilia and systemic symptoms has been reported . Interestingly, similar with previous study, we also show a Treg phenotype, suggesting strongly that some of these cases could arise from Tregs.…”

“…Excluding the current report, to date, 12 cases of benign atypical intralymphatic T‐cell proliferation, mostly CD30+, all but one affecting the skin and often associated with reactive/benign lesion, have been reported in the English literature . Interestingly, 7 (58%) of them showed oligoclonal or polyclonal T‐cell populations by PCR analysis .…”

“…To date, only 12 cases of atypical intralymphatic T‐cell proliferations, mostly CD30+, associated with cutaneous reactive/benign lesion, and following a benign clinical course, have been previously reported in the English literature . To the best of our knowledge, we report the first oral case of atypical intralymphatic CD30+ T‐cell lymphoid proliferation, initially suspicious for IVL, which showed spontaneous resolution after biopsy.…”

“…We report here the first oral case of benign atypical intralymphatic CD30+ T‐cell proliferation, also known as intralymphatic proliferation of T‐cell lymphoid blasts, which describes a subset of reactive atypical intralymphatic T‐cell proliferations, following a benign course, and it should be careful differentiated from IVL, an aggressive disease with poor prognosis …”

“…These cases affected six males and six females, with a range of 17 to 77 years (mean age, 44 years). The associated skin lesions were molluscum contagiosum, hemangioma, pyogenic granuloma, lichen sclerosus, hidradenitis suppurativa and prurigo nodule, as well as endometrial polyp and trauma . Recently, a case associated with drug rash with eosinophilia and systemic symptoms has been reported .…”