Intraluminal vesicle trafficking is involved in the secretion of base excision repair protein APE1
Isabella Parolini,
Monica Degrassi,
Francesca Spadaro
et al.
Abstract:The apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is an essential enzyme of the base excision repair pathway of non‐distorting DNA lesions. In response to genotoxic treatments, APE1 is highly secreted (sAPE1) in association with small‐extracellular vesicles (EVs). Interestingly, its presence in the serum of patients with hepatocellular or non‐small‐cell‐lung cancers may represent a prognostic biomarker. The mechanism driving APE1 to associate with EVs is unknown, but is of paramount importance in better… Show more
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