Intraluminal pressures and rate and magnitude of arterial constrictor responses

Davis, D. P.; Dow, Philip

doi:10.1152/ajplegacy.1972.222.2.415

Cited by 9 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Constriction increased with increasing pressure up to 120-140 mmHg and thereafter remained relatively constant to the highest pressure used, 240 mmHg. Segments of the dog dorsal pedal artery in situ likewise constricted against high transmural pressures, as assessed by an increase in perfusion pressure (Davis & Dow, 1972). A mean intraluminal pressure of 292 mmHg was required to prevent constriction.…”

Section: Discussionmentioning

confidence: 99%

“…Since the load on the muscle changes during vasoconstriction, there are two ways in which muscle load may be altered quickly; by changing the transmural pressure or by constricting the artery. The effect of changing the transmural pressure on the constriction of arteries by stimuli has been examined by a number of workers (Gerova' & Gero, 1967;Davis & Dow, 1972; Gore, 1972), but the effect of altering vessel dimensions by prior constriction does not seem to have been studied. Further, no attempt has been made to analyse the interaction between transmural pressure, prior vasoconstriction and constriction by additional stimulation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Muscle load and constriction of the rabbit ear artery.

Speden¹

1975

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The isolated, perfused ear artery of the rabbit has been used to examine the effect of alterations in muscle load on the constriction of arteries. The equilibrium muscle load, taken as the difference in wall stress between the relaxed and constricted artery at the same external radius, was varied by changing the transmural pressure and by constricting the artery.2. The equilibrium muscle load increased initially and then declined with decreasing external radius when the transmural pressure was kept constant. The maximum muscle load was reached when the relaxed external radius had been reduced by 11 % at 80 mmHg and by 4.5 % (relative to the radius at 80 mmHg) at 160 mmHg.3. Arteries from young rabbits (3-6 months in age) which were partially constricted by adrenaline or spontaneous activity responded better to 60 sec of 4 Hz field stimulation at transmural pressures above 100 mmHg than did relaxed arteries. Neither field stimulation nor high concentrations of noradrenaline ( > 800 ng/ml.) were able to constrict most arteries effectively at pressures above 160-170 mmHg unless partial constriction was present. The partial constriction reduced the load placed on the muscle by the same transmural pressure. Constriction during field stimulation was due largely to the release of neurotransmitter.4. Ear arteries from young and older rabbits differed little in their ability to constrict against different transmural pressures. The one major difference was a lesser maximum constriction of arteries from older rabbits (18-24 months in age). However, arteries from older rabbits constricted well at the higher transmural pressures only because wall thickening largely compensated for a decreased ability of the muscle to develop active tension. 5. It is concluded that a decrease in internal radius to wall thickness ratio by either sufficient partial vasoconstriction or by wall thickening

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Muscle load and constriction of the rabbit ear artery.

Speden¹

1975

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…For most vasoactive constrictor and dilator stimuli the magnitude of the responses is dependent on the initial vascular resistances in the hindlimb, gracilis muscle and the isolated perfused segments of small cutaneous arteries and veins (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). These findings resulted in the formulation of the law of initial values (LTV) first expressed by Wilder (2) and subsequently demonstrated by other investigators (3-1 3).…”

mentioning

confidence: 99%

Lack of Correlation Between Initial Vascular Resistance and Responses to Vasoconstrictor Stimuli in the Perfused Canine Hindpaw

Greenberg

Wilson

1974

Experimental Biology and Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…In the same aspect, relationships were considered between vasomotor reactions in some organs and the initial arterial tone or the level of transmural pressure [3,5,8,13]. Davis and Dow [3] found out an inverse rectilinear relationship between resistance changes produced by sympathetic stimulation in isolated segments and the resting level of intraluminal pressure. Mayer and Honing [8] revealed a negative correlation between the value of vasoconstriction or vasodilatation and the resistance in isolated gracilis muscle in response to stimulation under conditions of the constant flow perfusion.…”

Section: Discussionmentioning

confidence: 99%

The effects of the initial arterial tone on the pressure responses to phenylephrine

Osadtchy¹,

Balueva²,

Сергеев³

2000

Acta Physiologica Hungarica

View full text Add to dashboard Cite

The effect of the elevated arterial tone on pressure responses to stimulation of arterial alpha-adrenoreceptors by phenylephrine hydrochloride was studied in anesthetized Wistar rats. Different levels of the arterial tone and, hence of the mean arterial pressure, were established by means of angiotensin II infusion in the range from 101 to 160 mmHg. An elevation of the arterial tone led to a significant reduction of the arterial pressure and peripheral resistance rise produced by phenylephrine. The degree of relative reduction of the increase in the diastolic pressure exceeded 1.3 times that in the systolic pressure. The shifts of cardiac outputs remained unchanged. After cessation of angiotensin II infusion the restoration of the arterial pressure took place almost till the initial level. At this time the pressure effects of phenylephrine were tended to recovery. It is suggested that the elevated arterial tone attenuates the systemic pressure response to stimulation of arterial alpha-adrenoreceptors by a vascular mechanism based on a transmural pressure changes evoked by the constriction of the arterial vessels.

show abstract

Intraluminal pressures and rate and magnitude of arterial constrictor responses

Cited by 9 publications

References 0 publications

Muscle load and constriction of the rabbit ear artery.

Muscle load and constriction of the rabbit ear artery.

Lack of Correlation Between Initial Vascular Resistance and Responses to Vasoconstrictor Stimuli in the Perfused Canine Hindpaw

The effects of the initial arterial tone on the pressure responses to phenylephrine

Contact Info

Product

Resources

About