1971
DOI: 10.3109/00365527109181126
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Intraluminal pH of Duodenum and Jejunum in Fasting Subjects with Normal and Abnormal Gastric Or Pancreatic Function

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Cited by 55 publications
(19 citation statements)
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“…The diversity in molecular masses found after reduction suggests that the 'large fragment' is not a single unique combination of disulphide-linked peptides but rather a complex mixture. Nevertheless, these data indicate that peptides MSECCEQLEG(9-18), DESCRCEGLRMM (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and AENIPSRCNL SPMRCPMGGS(54-73) (of total mass 4675 Da) are probably the main components of this fragment. Figure 6A shows the potential cleavage sites of pepsin defined by the peptide cutter tool of ExPASy (http:// us.expasy.org/tools/peptidecutter/).…”
Section: Identification Of Peptides Resulting From Digestionmentioning
confidence: 93%
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“…The diversity in molecular masses found after reduction suggests that the 'large fragment' is not a single unique combination of disulphide-linked peptides but rather a complex mixture. Nevertheless, these data indicate that peptides MSECCEQLEG(9-18), DESCRCEGLRMM (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and AENIPSRCNL SPMRCPMGGS(54-73) (of total mass 4675 Da) are probably the main components of this fragment. Figure 6A shows the potential cleavage sites of pepsin defined by the peptide cutter tool of ExPASy (http:// us.expasy.org/tools/peptidecutter/).…”
Section: Identification Of Peptides Resulting From Digestionmentioning
confidence: 93%
“…Peptide peak 1 contained one mass, and peak 2 contained two masses that probably correspond to peptides derived from DESCRCEGLRMM (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) of the large subunit (Table 1). Pepsinolysis removed either the N-terminal Asp or the C-terminal Met, giving rise to peptides ESCRCEGLRM (21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and ESCRCE GLRMM(21-31), respectively.…”
Section: Identification Of Peptides Resulting From Digestionmentioning
confidence: 99%
See 2 more Smart Citations
“…With the relatively low buffer capacity of FaSSIF, pH 6.5, this would have not been possible since the resulting pH was measured to be pH ∼3. As the neutralizing capacity of the duodenum is relatively high and, with a normal pancreatic function in vivo, the average duodenal/jejunal pH range is rapidly attained (12), a pH of ∼3 would not be representative for our purpose. Moreover, such a low pH could contribute to the presence of the ionized and more soluble form of the drug and, thus, affect precipitation.…”
Section: Methodsmentioning
confidence: 99%