Intralipid Infusion in Neonates

Intralipid Effects on Preterm Neonate Serum

“…To isolate any IL-induced humoral changes, we used PMNLs obtained from adult donors. The results supplement those obtained by Wheeler and colleagues (7), who investigated only the cellular responses to IL. The assays were performed with pairs of sera taken before and after IL administration from the same patient.…”

“…Finally and not least important, different concentrations of IL have been used. Recently, the effect of IL infusion on neonate phagocytic function was investigated (7). At an in vivo infusion rate of I g/kg/24 h, no significant change in the chemiluminescent response and the migration ability of neonate PMNLs was observed.…”

“…For obvious reasons, fewer studies were performed on neonate phagocytic cells, although indirect measurements of macrophage functions have shown them to behave normally (6). Recently, no effect of IL was found on cord blood and neonate PMNL migratory and oxidative functions under specific conditions of TPN administration (7). Because neonates are known to have a transient defect of neutrophil migratory function (8)(9)(10)(11), it was interesting to investigate whether IL in itself has any effect when present in neonate serum.…”

4. Lipids

“…In vitro studies showed adverse effects of lipids on the survival of monocytes derived from children (91) and binding of IL‐2 to its receptors (92). On the other hand, in vivo studies in paediatric patients did not reveal adverse effects of lipid emulsions on complement factors (93) or polymorphonuclear leukocyte function (94,95).…”

Parenteral Nutrition in Infants and Children

“…There also is evidence the long chain fats may alter cellular function by changing membrane fluidity (104). Studies on pediatric patients and tissues have not revealed evidence suggesting an impairment of immune function by intravenous fat emulsions (106)(107)(108)(109)(110)(111)(112)(113).…”