Intralipid‐induced gastric relaxation is mediated via NO

Abstract

intraduodenal administration of intralipid induces a gastric relaxation via a NO-dependent mechanism.

Effects of the Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester (L-NAME) on Antropyloroduodenal Motility and Appetite in Response to Intraduodenal Lipid Infusion in Humans

“…The role of NO mechanisms is addressed optimally using speci c inhibitors of NO synthase (NOS), such as NG-L-arginine-methyl-ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA) (9-11, 13-17, 20). Administration of L-NAME stimulates pyloric (9,14,15) and duodenal (13) motility in the dog, ferret, and rat, impairs proximal gastric relaxation in the dog and chicken (10,12), and slows gastric emptying in the dog (11,14). Inhibition of NOS reduces short-term food intake in rodents, chickens, and in the marsupial, Sminthopsis crassicaudata (18)(19)(20).…”

“…Observations in animals suggest that nitric oxide (NO) may be an important modulator of gastroduodenal motility (9)(10)(11)(12)(13)(14)(15)(16)(17) and food intake (18)(19)(20)(21). The role of NO mechanisms is addressed optimally using speci c inhibitors of NO synthase (NOS), such as NG-L-arginine-methyl-ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA) (9-11, 13-17, 20).…”

Concomitant variations of gastric tone and duodenal motility in humans: Results of a placebo-controlled study assessing octreotide and sumatriptan

“…cholecystokinin [41] and glucagon-like peptide-1 (7Á/36)amide [42], and/or vagal stimulation [5] involving non-adrenergic, non-muscarinic, 5-hydroxytryptamine receptor activation on intrinsic neurones [43] and nitric oxide release [44,45]. Our results also suggest a role for somatostatin-dependent pathways.…”

Gastric Compliance, Sensation, and the Relaxation Response to a Nitric Oxide Donor in Health and Reflux Oesophagitis

“…Vagally induced gastric relaxation occurs via a nitric oxide-dependent mechanism [32, 33]. Duodenal distension also causes reflex gastric relaxation via nitric oxide [34]. Nitric oxide also mediates the cholinergic gastric relaxation produced by the neuroregulators, vasoactive intestinal polypeptide, adenosine triphosphate and prostaglandin E 2 [33, 35].…”