Intralesional vincristine as first-line therapy for nodular lesions in classic Kaposi sarcoma: a prospective study in 151 patients

Brambilla, Lucia; Bellinvia, Monica; Tourlaki, Athanasia; Scoppio, Biancamaria; Gaiani, Francesca; Boneschi, Vinicio

doi:10.1111/j.1365-2133.2009.09601.x

Cited by 64 publications

(43 citation statements)

References 29 publications

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“…Treatment modalities comprise local therapy for example surgery, radiotherapy and local chemotherapy such as injections of vinca alkaloids or local immune therapy by interferon,9 cis retinoid acid or imiquimod [18]–[23]. Patients with widespread disease may need systemic chemotherapeutic or immunologic medication.…”

Section: Discussionmentioning

confidence: 99%

Non-AIDS Associated Kaposi's Sarcoma: Clinical Features and Treatment Outcome

et al. 2011

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BackgroundKaposi's sarcoma (KS) in HIV negative patients is rare and has to be distinguished from AIDS associated KS. Two groups are at risk to develop non-AIDS related KS: elderly men mainly of Mediterranean origin and persons with iatrogenic immunosuppression.Patients and MethodsIn order to define risk-groups and major clinical features we retrospectively evaluated clinical data of all patients with non-AIDS associated KS presenting to the Department of Dermatology, University Hospital Tuebingen between 1987 and 2009. Data were extracted from the tumor registry of the Comprehensive Cancer Center Tuebingen and from patient records.Results20 patients with non-AIDS KS have been identified. The average age at KS onset was 66.6 years; the male-to-female-ratio was 3∶1. Most of the patients were immigrants from Mediterranean or Eastern European countries (60%). 15 cases of classic KS versus 5 cases of iatrogenic KS were observed. In 95% of the cases, KS was limited to the skin, without mucosal, lymph node or visceral manifestation. KS lesions were in all cases multiple and mostly bilateral, the most common localization was the skin of the lower extremities. Tumor control was achieved in nearly all cases by the use of local or systemic therapy. No patient died from KS.ConclusionsUnlike KS in AIDS patients, non-AIDS associated KS is a rather localized process which rarely involves lymph nodes or organs. It is mostly seen in elderly males from Mediterranean or Eastern European countries and in most cases responsive on local or systemic therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Non-AIDS Associated Kaposi's Sarcoma: Clinical Features and Treatment Outcome

et al. 2011

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“…Since these lesions often recur, but are less often life-threatening, one viable treatment strategy is recurrent use of local cryotherapy which typically resolves the isolated lesions [29]. Another well-described approach is the use of intralesional chemotherapeutics such as vincristine which are also efficacious [30]. …”

Section: Treatmentmentioning

confidence: 99%

An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment

Curtiss

Strazzulla

Friedman‐Kien

2016

Dermatol Ther (Heidelb)

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Kaposi’s sarcoma is an angioproliferative neoplasm which has undergone considerable epidemiologic change since the original description by Moritz Kaposi in the late 1800s. This opportunistic neoplasm gained widespread notoriety within the US during the height of the AIDS epidemic, where it was frequently found co-occurring with opportunistic infections. With the advent of modern antiretroviral therapies, as well as an increasing number of individuals on immunosuppression for autoimmune disease or organ transplantation, the landscape of the immunocompromised individual has changed. It is now important for clinicians to be mindful of Kaposi’s sarcoma manifesting in a growing variety of clinical contexts.

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“…Su curso clínico puede ser indolente o evolucionar con compromiso ganglionar o visceral, afectando seriamente la calidad de vida. Su tratamiento puede ser local o sistémico 14,15,20 . En nuestro país, el único dato publicado acerca de esta variedad ha sido aportado por el estudio realizado en el Hospital Clínico de la Universidad de Chile, que incluyó 12 pacientes con biopsias compatibles con SK.…”

Section: Discussionunclassified