Intralesional Verapamil Prevents the Progression of Peyronie’s Disease

Review of non-surgical treatment options for Peyronie's Disease

“…Therefore, repeated treatment over time would encourage better results. This is in contradistinction to the study by Bennett et al, 46 in which 94 subjects received 10 mg of intralesional verapamil biweekly, but for only six injections over 3 months. These authors concluded that intralesional verapamil in this regimen resulted in curve improvement in 22% and stabilization of curvature in 60%.…”

Intralesional hyaluronic acid: an innovative treatment for Peyronie’s disease

“…Also, unlike other research, our study measured improvements by use of a dynamic penile colour-duplex ultrasound study and not solely by measurement of penile curvature or by use of simple questionnaires [18,37,38]. It has been shown for some cases that an increase in the area of the disease (penile plaque) paradoxically led to an improvement in penile curvature [10].…”

Treatment of Peyronie’s Disease: 2012 Update

“…Finally, Rehman et al [40] performed the only randomized placebo-controlled study with verapamil injection therapy and demonstrated no statistically significant change in reducing penile curvature. In another recent uncontrolled study of 94 patients with PD, curvature was improved and stabilized in 18% and 60% of the study population, respectively [41]. The dilution of verapamil seems to contribute to its efficacy in reducing PD symptoms [42].…”