Intralesional Photodynamic Therapy: A Comment on ‘Pretreatment to Enhance Protoporphyrin IX Accumulation in Photodynamic Therapy’ by Gerritsen et al.

Torchia, Daniele; Cappugi, Pietro

doi:10.1159/000264668

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Low reactive oxygen species concentrations are involved in the promotion of cell growth and differentiation [20]. Pretreatments to enhance protoporphyrin IX accumulation or intralesional PDT with blue light might improve the therapy of recalcitrant plaques [21,22]. (3) Psoriasis is an auto-immune disorder with infiltration of the skin by immune cells.…”

Section: Discussionmentioning

confidence: 99%

Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

et al. 2011

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Background:Blue light has no known toxic effects on human skin, but reduces the proliferative capacity of keratinocytes in vitro. We therefore investigated the efficacy of blue light in the treatment of psoriasis vulgaris (PV). Methods: Forty patients with mild to moderate PV and bilateral plaques were assigned to two groups. Group 1 (n = 20) received irradiation at home with blue light (light-emitting diode, LED, emission maximum: 420 nm) once daily for 4 weeks. In parallel, group 2 (n = 20) performed irradiations with another blue light device (LED emission maximum: 453 nm). The contralateral control plaques remained untreated in both groups. Results: Thirty-seven patients completed the trial. The main study parameter, the difference of Local Psoriasis Severity Index (LPSI) scores of the irradiated plaques compared to the control plaques, showed statistically significant improvement after 4 weeks of treatment in both groups [group 1 (420 nm): n = 17, p = 0.04; group 2 (453 nm): n = 20, p = 0.04]. Accordingly, plaque status as assessed by both the physicians and the patients improved continuously during the 4 weeks of treatment and steadily declined thereafter. Conclusion: Blue light appears to be a promising treatment modality in PV that warrants further evaluation in larger studies.

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Section: Discussionmentioning

confidence: 99%

Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

et al. 2011

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“…Although a variety of treatments have been used to manage EMPD, including surgical excision [4,5,6,8], Mohs’ micrographic surgery [9,10], radiotherapy [11], local laser treatment [12], topical and intralesional photodynamic therapy [13,14], local imiquimod cream [15,16,17], topical and systemic chemotherapy [18,19], in the absence of an underlying carcinoma, a wide excision is generally accepted to be the best modality of treatment in China. Excision should reach the deep fascial layer and include some of the surrounding normal skin.…”

Section: Discussionmentioning

confidence: 99%

“…Intralesional photodynamic therapy, with proved effectiveness, a good safety profile and a good cost/effectiveness ratio for skin cancers, does not affect the compliance of patients and causes fewer side effects. Its only disadvantage is the difficulty to treat relatively large areas of field cancerization simultaneously [14]. In our series, we used intraoperative frozen-section biopsy for all cases and did not experience any false-negative results.…”

Section: Discussionmentioning

confidence: 99%

Frozen Section-Guided Wide Local Excision in the Treatment of Recurrent Scrotal Extramammary Paget’s Disease

Li²,

Xiang³

et al. 2012

Dermatology

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Background: A wide excision is generally accepted to be the standard modality of treatment for scrotal extramammary Paget’s disease (EMPD). The disease has a recurrence rate of about 10% and a second wide excision is still the chief treatment. We investigated the therapeutic methods for recurrent scrotal EMPD. Methods: We retrospectively studied the therapeutic methods and prognosis of 26 cases of recurrent EMPD. Seventy-two cases of primary scrotal EMPD served as controls. All of the cases were treated with frozen section-guided wide local excision. Results: There was no significant difference in the follow-up period of the recurrent cases before recurrence (p = 0.3228), local recurrence rate (p = 0.449), and total recurrence rate (p = 0.100) between the two groups, respectively. There is a favorable trend of worse mortality rate in the recurrence group (p = 0.056). The rate of inguinal lymph node metastasis was higher in the group with recurrent disease than in the control group (p = 0.017). Conclusion: Wide excision of the lesion still appears to be the most effective modality of treatment for recurrent scrotal Paget’s disease. Inguinal lymphadenectomy or sentinel lymph node biopsy should be offered to patients with primary lesions.

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“…To overcome this limitation, various pretreatments with de-bulking methods or the use of penetration enhancers have been attempted (6)(7)(8)(9). Still, many patients complain about the inconvenience associated with the long incubation period and the significant downtime until they have fully recovered after the de-bulking procedure (10).…”

Section: Introductionmentioning

confidence: 99%

New proposal for the treatment of viral warts with intralesional injection of 5-aminolevulinic acid photodynamic therapy

Kim

Hwang

et al. 2011

Journal of Dermatological Treatment

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Intralesional Photodynamic Therapy: A Comment on ‘Pretreatment to Enhance Protoporphyrin IX Accumulation in Photodynamic Therapy’ by Gerritsen et al.

Cited by 5 publications

References 10 publications

Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

Frozen Section-Guided Wide Local Excision in the Treatment of Recurrent Scrotal Extramammary Paget’s Disease

New proposal for the treatment of viral warts with intralesional injection of 5-aminolevulinic acid photodynamic therapy

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