Intralesional pentoxifylline in the treatment of lepromatous ulcers

Interventions for ulceration and other skin changes caused by nerve damage in leprosy

“…The studies evaluated various treatment interventions: low laser therapy (3 times per week) (Barreto 2010), light-emitting diode (LED; 20 minutes) (Lee 2012), weekly injected intralesional pentoxifylline (Mikhael 2015), daily to weekly zinc tape (Overbeek 1991;Söderberg 1982), zinc tape in addition to self-care and sandals (Walton 1986), padded moulded double-rocker plaster shoe (in addition to education) (Pring 1982), topical ketanserin (every 12 hours) (Salazar 2001), topical human amniotic membrane-mesenchymal stem cell-conditioned medium (every 3 days) (Prakoeswa 2018), daily pulsed magnetic fields (in addition to self-care and protective footwear) (Sarma 1997), PVC boots (daily) (Seboka 1998), daily wax therapy (Sharma 2005), and daily topical phenytoin dressings (Bansal 1993;Bhatia 2004).…”

Interventions for ulceration and other skin changes caused by nerve damage in leprosy

“…The trials took place in Brazil, Ethiopia, Egypt, Indonesia, Mexico, South Korea, and most in India. Four studies were hospital based (Bansal 1993;Bhatia 2004;Sharma 2005;Söderberg 1982), while nine were based at outpatient clinics (Barreto 2010;Overbeek 1991;Prakoeswa 2018;Pring 1982;Salazar 2001;Seboka 1998;Sarma 1997;Mikhael 2015;Walton 1986). One study included both in-and outpatients (Lee 2012).…”

“…The studies evaluated various treatment interventions: low laser therapy (3 times per week) (Barreto 2010), light-emitting diode (LED; 20 minutes) (Lee 2012), weekly injected intralesional pentoxifylline (Mikhael 2015), daily to weekly zinc tape (Overbeek 1991;Söderberg 1982), zinc tape in addition to self-care and sandals (Walton 1986), padded moulded double-rocker plaster shoe (in addition to education) (Pring 1982), topical ketanserin (every 12 hours) (Salazar 2001), topical human amniotic membrane-mesenchymal stem cell-conditioned medium (every 3 days) (Prakoeswa 2018), daily pulsed magnetic fields (in addition to self-care and protective footwear) (Sarma 1997), PVC boots (daily) (Seboka 1998), daily wax therapy (Sharma 2005), and daily topical phenytoin dressings (Bansal 1993;Bhatia 2004).…”

“…Four interventions were given for four weeks (Bansal 1993;Bhatia 2004;Sarma 1997;Walton 1986), three were given for six weeks (Pring 1982;Overbeek 1991;Sharma 2005), three were given for eight weeks (Mikhael 2015;Prakoeswa 2018;Söderberg 1982), two were given for 12 weeks (Barreto 2010;Salazar 2001), and one intervention was given for 12 months (Seboka 1998). Lee 2012 did not re-port duration of treatment period, but the whole study lasted eight months.…”

“…Cochrane Database of Systematic Reviews potentially quasi-randomised (Salazar 2001;Walton 1986), but as we were not sure, we assessed them as having unclear randomisation procedures along with four other studies (Lee 2012;Pring 1982;Sarma 1997;Seboka 1998). We assessed five studies as having adequate randomisation sequence generation (Barreto 2010;Bhatia 2004;Mikhael 2015;Prakoeswa 2018;Sharma 2005). We considered all studies at unclear risk of selection bias regarding allocation concealment due to limited information reported in the publications.…”