Intralesional methotrexate treatment for keratoacanthoma tumors: A retrospective study and review of the literature

Annest, Nicole M.; VanBeek, Marta; Arpey, Christopher J.; Whitaker, Duane C.

doi:10.1016/j.jaad.2006.12.017

Cited by 105 publications

(96 citation statements)

References 23 publications

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“…Annest et al [15 ]reported 38 cases of keratoacanthoma treated with 12.5–25 mg/ml of intralesional MTX with no prominent side effects.…”

Section: Discussionmentioning

confidence: 99%

Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Sarıcaoğlu

Turan³

2011

Dermatology

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Psoriasis is a common, chronic disease which affects nearly 3% of the population. The lifetime incidence of nail involvement increases up to 80–90% for psoriatic patients. Nail psoriasis is considered a significant social problem. Many topical agents have been used for psoriatic nails with various side effects and some benefits; management is currently inconclusive. Methotrexate (MTX) is a folic acid analog, which irreversibly binds to dehydrofolate reductase and blocks deoxyribonucleic acid synthesis. It is considered a potential treatment option for rapidly growing cells and has an anti-inflammatory effect through inhibition of the polyamine pathway in autoimmune diseases. Intralesional MTX has been used successfully for various indications. We present a case successfully treated with low-dose intralesional MTX with no observed side effects in a 26-year-old female psoriatic patient suffering from nail dystrophy. In contrast, conventional topical and systemic therapies have various side effects, which limit their use. We conclude that intralesional MTX injection seems to be a safe and effective treatment option for nail psoriasis; however, large controlled studies are needed.

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“…Annest et al [15 ]reported 38 cases of keratoacanthoma treated with 12.5–25 mg/ml of intralesional MTX with no prominent side effects.…”

Section: Discussionmentioning

confidence: 99%

Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Sarıcaoğlu

Turan³

2011

Dermatology

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“…In cases of typical keratoacanthomas, mainly on the face, intralesional chemotherapy (methotrexate, 5-FU, bleomycin) may be considered, although a benefit with respect to side-effects, patients' burden and outcome over surgery has never been demonstrated [58,59]. If the resolution is not straightforward, these tumours should be rapidly treated surgically like any other cSCC.…”

Section: Treatment Of Primary Sitementioning

confidence: 99%

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

Stratigos

Garbe

Lebbe

et al. 2015

European Journal of Cancer

423

369

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“…KAs are well-differentiated, squamous cell carcinomas with potential for metastasis (7). Therefore, it is important to treat these tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Other treatment modalities for KA include the following: Moh's excision, systemic retinoids, radiotherapy, curettage and electrodissection, intralesional 5-fluorouracil and intralesional methotrexate (MTX) (7). MTX is a folic acid analogue that irreversibly binds to dihydrofolate reductase, thereby blocking the formation of tetrahydrofolate and, subsequently, preventing the synthesis of the purine nucleotide thymidine (8), leading to a halt in DNA synthesis (9).…”

mentioning

confidence: 99%

Treatment of keratoacanthoma: Is intralesional methotrexate an option?

Patel¹,

Cervino²

2011

J Plastic Surgery

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Intralesional methotrexate treatment for keratoacanthoma tumors: A retrospective study and review of the literature

Cited by 105 publications

References 23 publications

Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Nail Psoriasis Successfully Treated with Intralesional Methotrexate: Case Report

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

Treatment of keratoacanthoma: Is intralesional methotrexate an option?

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