Intralesional interferon

Varnavides, C. K.; Henderson, C. A.; Cunliffe, W.J.

doi:10.3109/09546639709160513

Cited by 11 publications

(2 citation statements)

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“…CW may resolve spontaneously in 15%–63% of the cases 2–6 . Age, stress, sleep quality, socio‐economic status, and immune system of an individual are the factors affecting the spontaneous resolution 1,7 …”

Section: Introductionmentioning

confidence: 99%

“…1 CW may resolve spontaneously in 15%-63% of the cases. [2][3][4][5][6] Age, stress, sleep quality, socio-economic status, and immune system of an individual are the factors affecting the spontaneous resolution. 1,7 The mechanism of CW primarily involves derangement of the immune mechanisms, that is, inhibition of helper T cells stimulated release of interleukins, which is similar to various viral infections such as human immunodeficiency virus (HIV) and human T lymphotropic virus-4.…”

Section: Introductionmentioning

confidence: 99%

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A prospective randomized controlled study of Mycobacterium Indicus Pranii vaccine, Measles Mumps Rubella vaccine and Vitamin D3 in extragenital cutaneous warts

Lahoria

Singh

Bhardwaj

et al. 2023

J of Cosmetic Dermatology

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Participants: Two hundred patients. Methods: The intervention administered in the groups were normal saline (A), vitamin D 3 (B), MIP (C), and MMR (D). The injections were given into the largest wart at 2-weekly intervals until complete clearance or for a maximum of seven sittings. Posttreatment clearance of the injected wart and the distant wart was compared on the basis of change in wart number, percentage clearance, and mean time to complete clearance. Side effects were recorded.Results: A total of 197 patients were recruited. The mean percentage improvement in the injected and non-injected warts was 68.4% and 66.8%, respectively. Intention to treat analysis (ITT) showed that complete clearance of lesions in injected wart occurred in placebo, vit D 3 , MMR, and MIP arms in 64%, 66%, 58%, and 55% patients, respectively (p > 0.05), while in the non-injected warts in 62%, 64%, 52%, and 53%, respectively (p > 0.05). The mean time to achieve complete clearance of wart was fastest in MIP at 7.1 weeks followed by MMR at 7.2 weeks, VIT D 3 at 7.4 weeks and in placebo group 7.8 weeks (p > 0.05). Side effects noted were fever, pain, erythema, and swelling which was highest in VIT D 3 group (p < 0.05). Conclusion:The efficacy of immunotherapies was comparable to placebo with minimal side effects.

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Section: Introductionmentioning

confidence: 99%