Intralesional corticosteroid injection for the treatment of hidradenitis suppurativa: a multicenter retrospective clinical study

García‐Martínez, Francisco Javier; Rull, E. Vilarrasa; Salgado‐Boquete, Laura; Martorell, A.; Pascual, José C.; Hernández‐Martín, Ángela; Silvente, C.; Ciudad-Blanco, C.; Esteban, Eva; Alfageme, Fernando

doi:10.1080/09546634.2019.1655524

Cited by 20 publications

(35 citation statements)

References 17 publications

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“…In this study, the authors found a high rate of successful response after the infiltrations, similar to that of our study. Skin ultrasound was performed prior to treatment on most lesions and the authors concluded that this ultrasound examination may improve clinical response in all types of lesions as it allows a more accurate measurement of the depth and location of skin lesions 19 . However, ultrasound-assisted infiltrations were performed in less than half of the treated lesions.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa

Salvador‐Rodríguez

Arias‐Santiago

Molina-Leyva

2020

Sci Rep

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Corticosteroid infiltrations of lesions in hidradenitis suppurativa (HS) appear to be beneficial to acute flares. The aim of this study is to evaluate the effectiveness and safety of ultrasound-assisted intralesional corticosteroid infiltrations to HS lesions. Prospective cohort study between February 2017 and February 2019 on patients with mild to severe HS and one or more inflammatory lesions. The study intervention was ultrasound-assisted intralesional infiltration of triamcinolone acetonide 40 mg/ml. The main outcome was the complete response rate of infiltrated lesions versus non-infiltrated lesions. Two hundred and forty-seven infiltrated inflammatory lesions and 172 non-infiltrated lesions were included. At week 12, 81.1% (30/37) of nodules, 72.0% (108/150) of abscesses and 53.33% (32/60) of draining fistulas presented complete response versus 69.1% (47/68), 54.3% (38/70) and 35.3% (12/34) respectively for the non-infiltrated lesions. The Hurley stage negatively correlated with complete response for abscesses and draining fistulas at − 0.17 (SD 0.06) p < 0.01 and − 0.30 (SD 0.13) p < 0.02 respectively. Ultrasound-assisted corticosteroid infiltration is a useful technique for the treatment of inflammatory HS lesions, with high and sustained response rates, especially for abscesses and small to medium-size simple draining fistulas. The likelihood of response correlates negatively with the Hurley stage.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa

Salvador‐Rodríguez

Arias‐Santiago

Molina-Leyva

2020

Sci Rep

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“…For local treatment of selected large open wounds, use of negative-pressure therapy for a short period of time (1-4 weeks) followed by delayed reconstruction might be effective (6). Clinical experience supported the use of Intralesional corticosteroid injection (e.g., triamcinolone 3-5 mg) only for short-term control of acute and recalcitrant HS lesions (60,65). Pain is typically reduced fast and a reduction in edema, erythema, suppuration and lesion size occur after a few days.…”

Section: Local Therapy and Wound Carementioning

confidence: 99%

“…Pain is typically reduced fast and a reduction in edema, erythema, suppuration and lesion size occur after a few days. However, the long-term efficacy of this approach remains unclear and local side effects, most notably skin atrophy, have to be carefully monitored (31,65).…”

Section: Local Therapy and Wound Carementioning

confidence: 99%

Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm

2020

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Hidradenitis suppurativa is one of the most distressing dermatological conditions and has a significant negative impact on patients' quality of life. However, the exact pathogenic mechanisms remain incompletely understood and-therefore-efficient therapies are still lacking. The current manuscript focuses on new findings on its pathogenic mechanisms and aims to provide practical therapy recommendations.

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“…8 Intralesional injection of corticosteroids has been utilized for the treatment of inflammatory lesions of HS in a few case-series studies, in a placebo-controlled trial and it is mentioned in guidelines based on expert consensus. 1,[9][10][11][12][13][14] In particular, in 2016 Riis et al 10 reported 33 cases of HS in which nodular and abscess lesions were treated with intralesional infiltrations of triamcinolone with a significant reduction in lesion erythema, edema, suppuration, and size. Furthermore, a Canadian group reported the infiltration of corticosteroids in a third of their HS patients to successfully manage acute flare-ups of the disease and to reduce the use of systemic antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a Canadian group reported the infiltration of corticosteroids in a third of their HS patients to successfully manage acute flare-ups of the disease and to reduce the use of systemic antibiotics. 11 Recently, Alvarez et al 12 13 ; the authors showed that this therapy was useful to control acute and recalcitrant HS lesions. 13 On the other hand, no statistically significant difference was found between infiltration therapy of triamcinolone, at different doses, vs placebo in 67 lesions of 32 HS patients, in a double-blind, randomized, placebo-controlled clinical trial.…”

Section: Introductionmentioning

confidence: 99%

Intralesional ultrasound‐guided combined treatment with triamcinolone plus lincomycin in hidradenitis suppurativa: A pilot study

Fania

Clemente

Sampogna

et al. 2020

Dermatologic Therapy

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Hidradenitis suppurativa (HS) is a chronic, inflammatory, disease of the hair follicle. Intralesional corticosteroid treatment in HS patients has been reported, and while several data described this route of administration as an efficient delivery system, its efficacy is still debated. The aim of this study was to explore the clinical efficacy and the effect on quality of life (QoL) of an innovative intralesional treatment in HS patients. This was an interventional prospective study. The treatment consisted of two intralesional ultrasound-guided injections of triamcinolone plus lincomycin, at baseline and after 2 weeks. Lesions and QoL were evaluated at baseline and at 4 weeks following intralesional therapy. All clinical variables of 36 HS patients significantly improved after 4 weeks. Mean values of the visual analog scale (VAS) pain decreased from 4.6 to

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Intralesional corticosteroid injection for the treatment of hidradenitis suppurativa: a multicenter retrospective clinical study

Cited by 20 publications

References 17 publications

Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa

Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa

Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm

Intralesional ultrasound‐guided combined treatment with triamcinolone plus lincomycin in hidradenitis suppurativa: A pilot study

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