Intralesional botulinum toxin A injection for treating nodular scabies

Lü, Yan; Qi, Xinyu; Zhou, Xianyi; Chen, Xuyang; Liu, Kangxing; Yang, Yonggang; Mao, Zuhao; Wu, Zhiyang; Zheng, Yi; Hu, Yongxuan; Hu, Yanqing

doi:10.1111/dth.14163

Cited by 4 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,7,8 The strategic treatments for NS and its itch are limited and remain challenging sometimes, which include potent topical, intralesional, and systemic corticosteroids, topical calcineurin inhibitors and crotamiton, cryotherapy, surgical excision of the lesions, and even injection of intralesional botulinum toxin A used alone or in a different combination, showing various response with possibility of recurrence. 1,7,11,15,16 The effect of antihistamines for scabies is limited, however, which can be used to improve the patient's somnus and help alleviate pruritus. 1,3,4,7,15,16 In rare instances, the sarcoptic nodules are difficult to eradicate as in the present.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 7 Histamine pathway is not thought the main mediator that contributed to the pathomechanism of sarcoptic itch, 4 , 7 although antihistamines have been used for the treatment of such conditions. 1 , 3 , 4 , 7 , 15 , 16 However, non-histaminergic pathways such as host–mite interaction including both type I and type IV hypersensitivity reaction, and secondary microbial infection and never sensitization are considered to be the main reasons for scabies pruritis. 7 , 11 , 15 The recent studies from the animal model showed that transient receptor potential vanilloid-1, transient receptor potential ankyrin 1, protease-activated receptor 2, and tryptase + cells had played important roles in the non-histaminergic itch of scabies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recalcitrant nodular scabies showing excellent response to tofacitinib: five case reports

Zhao,

Lu,

Liu

et al. 2023

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

Scabies is a contagious skin condition caused by Sarcoptes scabiei, and it is always associated with an intense, unbearable, nocturnal deteriorating itch. Its presentations include classic burrows, erythema, pruritic papules, pustules, vesicles, and inflammatory nodules, with diffuse or localized distribution on the finger webs, wrist flexors, elbows, axillae, buttocks, genitalia, and breasts. Nodular scabies is an uncommon clinical variant of scabies. Its management is still challenging for some patients up to date, although topical, intralesional or systemic corticosteroids, topical calcineurin inhibitors, and crotamiton as well as cryotherapy alone or in different combinations are used. We here report five male patients of nodular scabies, aged between 14 and 25 years, who had classical scabies that had been cured by sulfur ointment for at least 4 weeks except for their itching nodules, and their residual pruritic nodules also failed in previous treatments including antihistamines, topical applying and intralesional injection of steroids as well as topical tacrolimus in different combinations before being recruited to this study. The patients were administered tofacitinib 5 mg, twice a day, which led to excellent and rapid improvement for both lesions and symptoms after 1–4 weeks of treatment, respectively, without any associations. During 6 months of follow-up, only one had re-infection of scabies associated with nodules that were cured by sulfur ointment and tofacitinib again. No adverse reaction was observed. The present results suggested that tofacitinib might be a potential agent for nodular scabies with excellent response.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recalcitrant nodular scabies showing excellent response to tofacitinib: five case reports

Zhao,

Lu,

Liu

et al. 2023

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

show abstract

“…Janus Kinase (JAK)) inhibitors 144 TRP channels TRP channel modulators (e.g. topical capsaicin, topical calcineurin inhibitors, topical camphor, topical menthol, topical strontium hydrogel formulation (TriCalm TM ), and botulinum toxin) [152][153][154] successful in reducing localized scabies itch (i.e. nodular scabies).…”

Section: Control Of Scabies Itch (Table 2)mentioning

confidence: 99%

“…nodular scabies). [152][153][154] The topicals (capsaicin, in particular) may cause a transient burning sensation and should be applied with care (i.e. avoid excoriated areas).…”

Section: Control Of Scabies Itch (Table 2)mentioning

confidence: 99%

“…topical capsaicin, topical calcineurin inhibitors, topical camphor, topical menthol, topical strontium hydrogel formulation (TriCalm™) and botulinum toxin) 146–151 have been reported successful in reducing localized scabies itch (i.e. nodular scabies) 152–154 . The topicals (capsaicin, in particular) may cause a transient burning sensation and should be applied with care (i.e.…”

Section: Management Of Scabies Itchmentioning

confidence: 99%

See 1 more Smart Citation

Scabies itch: an update on neuroimmune interactions and novel targets

Kim

Hashimoto

Fischer

et al. 2021

Acad Dermatol Venereol

View full text Add to dashboard Cite

Frequently described as 'the worst itch' one can ever experience scabies itch is the hallmark of Sarcoptes scabiei mite infestation. Notably, the itchiness often persists for weeks despite scabicides therapy. The mechanism of scabies itch is not yet fully understood, and effective treatment modalities are still missing which can severely affect the quality of life.The aim of this review is to provide an overview of the scope of itch in scabies and highlight candidate mechanisms underlying this itch. We herein discuss scabies itch, with a focus on the nature, candidate underlying mechanisms and treatment options. We also synthesize this information with current understanding of the mechanisms contributing to non-histaminergic itch in other conditions. Itch is a major problem in scabies and can lead to grave consequences. We provide the latest insights on host-mite interaction, secondary microbial infection and neural sensitization with special emphasis on keratinocytes and mast cells to better understand the mechanism of itch in scabies. Also, the most relevant current modalities remaining under investigation that possess promising perspectives for scabies itch (i.e. proteaseactivated receptor-2 (PAR-2) inhibitor, Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist) are discussed. Greater understanding of these diverse mechanisms may provide a rational basis for the development of improved and targeted approaches to control itch in individuals with scabies.

show abstract