Intralesional Bleomycin Sclerotherapy in Children with Lymphangiomas: A Review Article

Erikçi, Volkan Sarper

doi:10.33552/asoaj.2020.02.000539

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…This complication is dose‐dependent and the systemic cumulative lifetime dose is shown to be 400 mg 6,7 . We limited the dosage per sclerotherapy session to less than 1 mg/kg or not more than 15 mg in total, which was described by Yura and subsequently reported in other literatures 8,9 . The dosage used in each sclerotherapy session was clearly logged in the medical records.…”

Section: Discussionmentioning

confidence: 99%

Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong

et al. 2022

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Background: Vascular malformations represent a wide spectrum of disorders in children. Recently, interstitial bleomycin sclerotherapy has been shown to be a safe and effective treatment for selected cases of vascular malformation in children and adults.Aim: To evaluate the short-term outcome and safety of interstitial bleomycin sclerotherapy in children with vascular malformations.Methods: This is a retrospective study in which patients under 18 years old with vascular malformation undergoing bleomycin sclerotherapy between August 2019 and January 2022 in Hong Kong were included. Relevant demographics of the included patients were collected. Short-term outcomes including clinical response, immediate and early complications were evaluated.Results: Four patients who aged from 4 to 8 years old were identified, three with lymphatic malformation and one with arteriovenous malformation. A total of eight sessions of interstitial bleomycin sclerotherapy were performed. Three of them reported clinical response with either reduction in lesion size or reduction in discomfort or disfigurement. No immediate complication was reported. However, one of them experienced post-operative hyperpigmentation with scratch marks. Conclusion:The experience in the use of interstitial bleomycin sclerotherapy in children with vascular malformations is still limited in our locality. Further study with larger cohorts and longer follow-up is required to further establish its efficacy and safety profile in paediatric patients.

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Section: Discussionmentioning

confidence: 99%

Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong

et al. 2022

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“…The search for the ideal postnatal treatment remains a dilemma. These include various sclerotherapy techniques, utilizing substances such as Bleomycin, Picibanil (OK‐432), as well as others 17,18 . The importance of early diagnosis and an interdisciplinary healthcare team approach allows for the best, individualized care for these patients.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Fetal Lymphangioma: A Case Series

Diaz-Primera¹,

Sánchez-Jimenez²,

Marin-Concha³

et al. 2021

J of Ultrasound Medicine

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Fetal lymphangioma is an uncommon congenital malformation that is mainly comprised of the subcutaneous tissue of the neck. This malformation can develop in other areas like the thoracic and axillary regions, though rarely. We report 6 consecutive cases of lymphatic malformation in a fetal center in Dominican Republic. In our case series fetal chest lymphangiomas were present in 2 fetuses. In addition, 2 cases of axillary lymphangiomas also involved the thoracic region. Adequate management by a multidiciplinary team is necessary to provide a better approach to delivery.

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“…Many sclerosing agents have been tried, thus far including sodium morrhuate, sodium tetradecyl sulphate, absolute ethanol, ethibloc, OK-432 and bleomycin. [ 6 – 8 ] Percutaneous sclerotherapy is a safe and effective treatment modality to reduce bleeding during surgery and shrink the size of the lesion. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Intralesional Bleomycin Sclerotherapy for Non-Invasive Management of Low Flow Vascular Malformations - A Prospective Clinical Study

Jan

Shah

Beigh

2022

Annals of Maxillofacial Surgery

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Introduction: Bleomycin, a cytotoxic and antitumour drug, is safe and effective in the management of vascular anomalies prevalent in the head and neck region. The aim of our study was to evaluate the effect of intralesional bleomycin injection in vascular malformations (VMs), especially venous and lymphatic malformations present extracranially on the face, lips and intraorally. Subjects and Methods: This prospective clinical study was conducted in the Department of Oral and Maxillofacial Surgery, Government Dental College, Srinagar. The study included 30 patients with low-flow VMs (LFVMs) wherein the effectiveness of intralesional bleomycin sclerotherapy was evaluated. The recorded data was compiled and continuous variables were expressed as mean ± standard deviation and categorical variables were summarised as frequency and percentages. Results: Complete resolution (cure) was observed in 11 patients (36.66%), marked improvement in 17 patients (56.66%) and mild improvement in two patients (6.66%). Local complications were superficial ulcerations in 14 patients (46.66%) and hyperpigmentation in one patient (3.33%). Systemic complications in the form of flu like symptoms, nausea or vomiting were not reported in any of the above-mentioned patients. Signs of pulmonary fibrosis and/or hypertension were also not reported in any of the above cases. Conclusion: Intralesional bleomycin injection is a potent and safe therapeutic alternative for the treatment of haemangiomas and LFVMs. Such patients can be managed on an outpatient basis without the need of any extensive surgery, expensive armamentarium and with only minor complications.

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Intralesional Bleomycin Sclerotherapy in Children with Lymphangiomas: A Review Article

Cited by 3 publications

References 16 publications

Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong

Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong

Prenatal Diagnosis of Fetal Lymphangioma: A Case Series

Therapeutic Effects of Intralesional Bleomycin Sclerotherapy for Non-Invasive Management of Low Flow Vascular Malformations - A Prospective Clinical Study

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