Intralateral hypothalamic area injection of isoproterenol and propranolol affects food and water intake in broilers

Abstract

The role played by adrenergic system in water intake, especially food intake, has long been known in mammals. In avian species, there have been many experiments exploring the effects of the adrenergic system in different sites in the central nervous system in meat- and egg-type poultry. This study was designed to examine the possible effects of intralateral hypothalamic area (ILHy) microinjections of a beta-adrenergic agonist, isoproterenol, and a beta-adrenoceptor blocker, propranolol, on food and water intake in 3-h food-deprived and 3-h water-deprived broiler cockerels. Our findings suggest that the beta-adrenergic system directly affects food especially water intake in broilers. Although isoproterenol significantly (P < or = 0.05) decreased food intake for the first 15 min, it reduced food intake during the experiment. Isoproterenol reduced water intake significantly (P < or = 0.05), which was abolished by pretreatment with propranolol. It is proposed that beta-adrenoceptors in LHy play a direct and indirect role in the regulation of food especially water intake in broiler cockerels.

Possible Involvement of Beta-Adrenergic Receptors on Nociceptin/Orphanin FQ Induced Food Consumption in Male Rats

“…In the peripheral nervous system, as well as the brain, isoproterenol appears to have only beta-adrenergic activity. High dosages of beta adrenergic receptor agonists induce cardiomyocyte necrosis and interstitial fibrosis in rats [5]. Our preliminary results from similar studies on food and water consumption suggest that peripheral injections of isoproterenol, increased food and water consumption and this effect was blocked by i.p.…”

Central regulation of food intake in mammals and birds: a review

“…Noradrenaline excites approximately half of the neurons in the ARC, probably due to a direct postsynaptic response through α 1 or β receptors [10] . It is well-documented that administration of β-adrenergic receptor agonist decreases food intake in rats [60][61][62] and poultry [63,64] . Intraperitoneal (IP) administration of β 3 receptor agonist decreases food intake in rat [62] .…”

Distinct Amygdalar AMPAergic/GABAergic Mechanisms Promote Anxiolitic-Like Effects in an Unpredictable Stress Model of the Hamster

“…In addition, the Gluergic excitatory neuroreceptor system appears to play a key role not only on stressful dependent behavioral activities such as feeding (Baghbanzadeh et al 2010) but also on neuronal development plus plasticity events during injury and disease (Lujan et al 2005;Yang et al 2011). As a consequence, it should not be surprising that increased argyrophilic reactions following chronically stress-dependent responses were mostly obtained in neurodegenerated limbic regions like COR and HIP that are also involved with emotional along with sensorimotor performances (Cook and Wellman 2004;Radley et al 2004;Mitra et al 2005;McEwen 2007;Sherin 2011).…”