Intrahypothalamic implants of testosterone or dihydrotestosterone in neonatal female rats with reference to induction of sterility.

Hayashi, Shinji

doi:10.1507/endocrj1954.24.595

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1979

1990

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“…We have attempted many times to demonstrate a receptor in the neonatal rat using 3H-DHT and 3H-R188I as the ligand, but have been unable to do so [unpublished data]. The steroid specificity of the proposed system may be the reason we were unable to demonstrate receptor and why DHT im planted in the brain will not induce masculinization during the critical period while the same quantity of testosterone will [15], There have been reports of androgen receptors in the neonatal rat brain but no mention as to whether they bound DHT [19,22]. Earlier work indicated that they do not appear until day 5-7.…”

Section: Discussionmentioning

confidence: 99%