Intrahippocampal transplantation of dental pulp stem cells improved memory function and reduced neuroinflammation-induced cell death in the rat’s model of seizure
Aliakbar Shoja,
Mojtaba Sani,
Nika Balaghirad
et al.
Abstract:Background
Epilepsy is a prevalent neurological disorder that significantly reduces the patient's quality of life. The present study aims to evaluate whether dental pulp stem cells (DPSCs) transplant effectively decreases inflammation and cell death in the brain cells to reduce seizure damage.
Methods
A seizure was induced in rats using intraperitoneal injections of pentylenetetrazole (PTZ). In the PTZ + DPSC group, bilateral hippocampal transplantation of DPSCs in PTZ-lesioned rat models was conducted. Afte… Show more
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