2019
DOI: 10.1016/j.bbr.2018.11.021
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Intrahippocampal administration of 5-HT6 receptor drugs on memory consolidation and amnesia protocols

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Cited by 9 publications
(6 citation statements)
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“…The injection of 5-HT 6 agonists such as EMD-386088, EMDT and WAY-208466 in different doses and routes of administration induces procognitive actions in models such as MWM, passive avoidance task, autoshaping memory task and NORT. Putatively, the effects of these drugs may be related to the increase in several molecules at the hippocampus including cAMP response element-binding, brain-derived neurotrophic factor, dopamine, glutamate, gamma-aminobutyric acid and acetylcholine, phospho-Thr (202/204)-Erk1/2, c-fos and Arc (Pereira et al, 2015;Jastrzębska et al, 2018;Aparicio-Nava et al, 2019). Surprisingly, the 5-HT 6 R antagonists SB-258585, SB-399885 and SUVN-502 also exert procognitive effects in the NORT, the MWM and the radial maze through different mechanisms of action.…”
Section: Discussionmentioning
confidence: 99%
“…The injection of 5-HT 6 agonists such as EMD-386088, EMDT and WAY-208466 in different doses and routes of administration induces procognitive actions in models such as MWM, passive avoidance task, autoshaping memory task and NORT. Putatively, the effects of these drugs may be related to the increase in several molecules at the hippocampus including cAMP response element-binding, brain-derived neurotrophic factor, dopamine, glutamate, gamma-aminobutyric acid and acetylcholine, phospho-Thr (202/204)-Erk1/2, c-fos and Arc (Pereira et al, 2015;Jastrzębska et al, 2018;Aparicio-Nava et al, 2019). Surprisingly, the 5-HT 6 R antagonists SB-258585, SB-399885 and SUVN-502 also exert procognitive effects in the NORT, the MWM and the radial maze through different mechanisms of action.…”
Section: Discussionmentioning
confidence: 99%
“…At present, a lot of knowledge about memory comes from the study of memory impairment, especially amnesia. [35][36][37]. Other neurological diseases, such as Alzheimer's disease [38], Parkinson's disease [39,40] and Korsakoff's syndrome [41] also accompany with impaired memory.…”
Section: Discussionmentioning
confidence: 99%
“…This is partly due to the information is assumed to be transiently stored in short-term memory while it is considered to integrate long-term memory permanently [38]. At present, a lot of knowledge about memory comes from the study of memory impairment, especially amnesia [39][40][41]. Other neurological diseases, such as Alzheimer's disease [42], Parkinson's disease [43,44]and Korsakoff's syndrome [45] also accompany with impaired memory.…”
Section: Discussionmentioning
confidence: 99%