A 51-year-old man was referred to us with a diagnosis of chronic hepatitis, secondary to hepatitis C infection after receiving blood transfusion at splenectomy for traffic accident at 16-year age. He had undergone ultrasonographic examination, and a homogeneous and slight hyperechoic mass, measuring 18 × 20 mm in diameter, was detected in liver segment IV (Figure 1). Contrast-enhanced computed tomography (CT) scan showing a marked hyper-attenuation of the lesion during the hepatic arterial phase and a fast wash-out during the venous phase, mimicking hepatocellular carcinoma (HCC) (Figure 2).There are no typical radiological features of intrahepatic splenosis and it is usually difficult to distinguish this condition from other liver tumors. We performed an echo-guided tumor biopsy. Histopathology showed a splenic tissue containing lymphocytes and myeloid cells in sinusoids surrounded by fibrous capsule (Figure 3). We confirmed the diagnosis of hepatic splenosis. Splenosis was firstly reported by Buchbinder and Lipkoff in 1939 [1]. Although it is believed to occur in up to 67% of cases with