Intrahepatic portal vein blood volume estimated by non-contrast magnetic resonance imaging for the assessment of portal hypertension

Aguirre-Reyes, Daniel; Sotelo, Julio; Arab, Juan Pablo; Arrese, Marco; Tejos, Rodrigo; Irarrázaval, Pablo; Tejos, Cristián; Uribe, Sergio; Andía, Marcelo E.

doi:10.1016/j.mri.2015.06.016

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…Tissue volumes for the physiological compartments in the preterm neonatal population were allometrically scaled from tissue volumes of a term neonate with a fixed exponent of 1 ( Table ). Volume of the portal vein was assumed to be 77.8% of the hepatic volume . The hepatic blood flow was assumed to allometrically scale from a term neonate with a fixed exponent of 0.75.…”

Section: Methodsmentioning

confidence: 99%

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First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

Brussee

Krekels

et al. 2018

CPT Pharmacom & Syst Pharma

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To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1‐OH‐midazolam concentrations from 37 preterm neonates (gestational age 26–34 weeks) receiving midazolam orally and/or via a 30‐minute intravenous infusion, intrinsic clearance in the gut wall and liver were found to be very low, with lower values in the gut wall (0.0196 and 6.7 L/h, respectively). This results in a highly variable and high total oral bioavailability of 92.1% (range, 67–95%) in preterm neonates, whereas this is around 30% in adults. This approach in which intestinal and hepatic clearance were separately estimated shows that the high bioavailability in preterm neonates is explained by, likely age‐related, low CYP3A activity in the liver and even lower CYP3A activity in the gut wall.

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Section: Methodsmentioning

confidence: 99%

“…Volume of the portal vein was assumed to be 77.8% of the hepatic volume. 24 The hepatic blood flow was assumed to allometrically scale from a term neonate 7 with a fixed exponent of 0.75. Blood flows in the other tissues were assumed to be proportional to the hepatic blood flow (Table 1 5 ,7,25,32 ).…”

Section: Model Developmentmentioning

confidence: 99%

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

Brussee

Krekels

et al. 2018

CPT Pharmacom & Syst Pharma

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“…However, in hepatic perfusion with multislice spiral computed tomography, PPI of patients with cirrhosis were significantly lower compared with the control group 21 . Similarly, noncontrast MRI techniques showed that the portal vein blood volume that flows into the intrahepatic volume in one and two cardiac cycles is significantly lower in portal hypertension patients than in healthy volunteers 22 .…”

Section: Discussionmentioning

confidence: 94%

99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis

Liu

Dong

Líu

et al. 2018

Nuclear Medicine Communications

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ObjectiveThe aim was to perform exploratory research on the application of technetium phytate (99mTc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity.Patients and methodsA total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child–Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system. PPIs were compared and analyzed, respectively, among the three and five groups. The correlations between PPIs and major biochemical indices of liver function were also analyzed. One-way analysis of variance was used to compare the PPIs among the various groups and a nonparametric Spearman test was used to analyze the correlations between PPIs and various biochemical indices.ResultsPPIs of the five groups decreased gradually from stage 1 to stage 5 (73.03±8.49, 52.96±16.22, 46.24±15.25, 29.99±17.36, and 11.50±6.37, respectively); with the exception of the difference between stages 2 and 3 (P=0.252), the differences between the remaining groups were statistically significant (P<0.05). The PPI showed positive correlations with serum total protein, serum albumin, and albumin/globulin results (r=0.292, 0.559, 0.520, respectively; P<0.05), and negative correlations with serum globulin (r=−0.366, P<0.05).ConclusionTechnetium phytate PPI could be a promising noninvasive and effective method for predicting the complications of hepatitis B cirrhosis and their severity; a lower PPI value indicates a higher severity of complications for hepatitis B cirrhosis patients. PPI can provide very meaningful reference data for clinical practice.

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“…New magnetic resonance (MR) sequences may enable the investigator to quantify blood volume in vessels and organs using noncontrast MR imaging such as a venography technique or velocity-selective pulse trains. 83,84 These new approaches will allow us not only to quantify blood volume without contrast in the vascular system but also in organs such as liver, brain and spleen. New positron emission tomography tracers that can precisely track CD8 + T cells are also under development.…”

Section: Prospectsmentioning

confidence: 99%

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Lambin

Lieverse

Eckert

et al. 2020

Seminars in Radiation Oncology

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show abstract

Intrahepatic portal vein blood volume estimated by non-contrast magnetic resonance imaging for the assessment of portal hypertension

Cited by 6 publications

References 36 publications

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

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