Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast-enhanced ultrasound

Vilana, R.; Forner, Alejandro; Bianchi, Luís; García-Criado, Ángeles; Rimola, Jordi; Lope, Carlos Rodríguez de; Reig, María; Ayuso, Carmen; Brú, Concepció; Bruix, Jordi

doi:10.1002/hep.23600

Cited by 282 publications

(249 citation statements)

References 31 publications

Supporting

Mentioning

232

Contrasting

Unclassified

Order By: Relevance

“…These were peripheral irregular rim-like hyperenhancement, heterogeneous hyperenhancement, homogeneous hyperenhancement and heterogeneous hypo-enhancement [10,[14][15][16][17]. In the present study, the most common type of ICC was the mass-forming type (80%).…”

Section: Discussionsupporting

confidence: 46%

“…In addition, different morphological subtypes tended to exhibit distinct enhancement characteristics on CT [7,8,[11][12][13]. On CEUS, besides the specific feature of peripheral rim-like hyperenhancement, diverse imaging findings of ICC were reported [9,10,[14][15][16][17]. These different CEUS appearances may reflect the differences in pathological subtypes or components of ICC.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination

Xu¹,

Chen²,

Liu³

et al. 2012

The British Journal of Radiology

View full text Add to dashboard Cite

Objective: To investigate the correlation between enhancement patterns of intrahepatic cholangiocarcinoma (ICC) on contrast-enhanced ultrasound (CEUS) and pathological findings. Methods: The CEUS enhancement patterns of 40 pathologically proven ICC lesions were retrospectively analysed. Pathologically, the degree of tumour cell and fibrosis distribution in the lesion was semi-quantitatively evaluated. Results: 4 enhancement patterns were observed in the arterial phase for 32 massforming ICCs: peripheral rim-like hyperenhancement (n519); heterogeneous hyperenhancement (n56); homogeneous hyperenhancement (n53); and heterogeneous hypo-enhancement (n54). Among the four enhancement patterns, the differences in tumour cell distribution were statistically significant (p,0.05). The hyperenhancing area on CEUS corresponded to more tumour cells for mass-forming ICCs. Heterogeneous hyperenhancement (n52) and heterogeneous hypo-enhancement (n52) were observed in the arterial phase for four periductal infiltrating ICCs. In this subtype, fibrosis was more commonly found in the lesions. Heterogeneous hyperenhancement (n51) and homogeneous hyperenhancement (n53) were observed in the arterial phase for four intraductal growing ICCs. This subtype tended to have abundant tumour cells. Conclusion: The CEUS findings of ICC relate to the degree of carcinoma cell proliferation at pathological examination. Hyperenhancing areas in the tumour always indicated increased density of cancer cells.

show abstract

Section: Discussionsupporting

confidence: 46%

mentioning

confidence: 97%

Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination

Xu¹,

Chen²,

Liu³

et al. 2012

The British Journal of Radiology

View full text Add to dashboard Cite

show abstract

“…Intrahepatic cholangiocarcinoma (ICC) is a tough diagnostic challenge duo to its asymptomatic clinical features and atypical imaging characteristics [17,18]. Commonly, it is more difficult to distinguish smaller ICC (diameter ≤3 cm) from HCC on CEUS, corresponding to more frequently appeared homogeneous hyperenhancement [19]. In our study, similar with the entire clips, the 0-1min clips could correct diagnose 14 in 16 patients.…”

Section: Discussionmentioning

confidence: 61%

Analysis of only 0-1 min clip or 1-4 min Clip for focal liver lesions during contrast-enhanced ultrasonography

Zhang¹,

Yi²,

Ai³

et al. 2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…However, a few years later, Vilana et al reported that intrahepatic cholangiocellular carcinoma (ICC) in cirrhotic liver may not be clearly distinguishable from HCC at CEUS [20]. A total of 21 patients were evaluated.…”

mentioning

confidence: 99%

“…As reported by D'Onofrio et al, the behavior of ICC at CEUS is different from the one in CT. During the late phase, ICC appears hypervascular at CT, because of desmoplastic reaction due to fibrotic component, while at CEUS it appears hypovascular [22]. In these cases CEUS should not be used as the sole imaging technique for conclusive hepatocellular carcinoma diagnosis and if the MRI does not display the diagnostic vascular pattern, a confirmatory biopsy is mandatory [20]. More recently, de Sio et al enrolled 282 cirrhotic patients who underwent CEUS and subsequent biopsy with histological evaluation as the gold standard for correct classification of FLLs.…”

mentioning

confidence: 99%

Recall strategies for patients found to have a nodule in cirrhosis: is there still a role for CEUS?

et al. 2015

View full text Add to dashboard Cite

Development of liver tumors and their evolution to hepatocellular carcinoma (HCC) is a multi-step process in which different HCC-etiologies induce continuous rounds of hepatocyte damage and regeneration. Over an extended time, this triggers cirrhosis which is a pathological state of the liver in which lesions can progress to become dysplastic nodules. Later, these nodules may evolve into HCC and occasionally generate metastatic events. To provide optimal care, patients with liver cancer should be managed using a multidisciplinary approach in specialized centers in which all the diagnostic and therapeutic resources are available. Among the different imaging modalities the introduction on contrast agents for ultrasound use has opened new further applications in different clinical settings. In fact, contrast enhanced ultrasound (CEUS) has been applied for more than ten years and plays increasingly important roles in the management of HCC. Since early 2000, international societies including the American Association for the Study of Liver Diseases (AASLD), the European Association for the Study of the Liver (EASL), the Asian Pacific association for the Study of the Liver (APASL), the Japanese society of Hepatology (JSH), the Italian society for the study of the liver (AISF), the World Federation for Ultrasound in Medicine and Biology (WFUMB), and the European Federation of Societies for Ultrasound in Medicine and Biology (EFUSMB) have discussed the important role of CEUS in the diagnosis of HCC. In the present review an update of the literature and a detailed discussion of the present Guidelines regarding the role of CEUS in the evaluation of nodules in cirrhotic patients is offered.

show abstract

Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast-enhanced ultrasound

Cited by 282 publications

References 31 publications

Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination

Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination

Analysis of only 0-1 min clip or 1-4 min Clip for focal liver lesions during contrast-enhanced ultrasonography

Recall strategies for patients found to have a nodule in cirrhosis: is there still a role for CEUS?

Contact Info

Product

Resources

About