Intrahepatic Microvascular Changes in Carbon Tetrachloride‐induced Cirrhotic Livers in the Rat

Koo, Anthony; Liang, I. Y. S.; Cheng, Kwok-Kew

doi:10.1038/icb.1976.28

Cited by 7 publications

(1 citation statement)

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“…Hepatic microvascular changes in liver cirrhosis 3535 due to hepatitis B virus (29/39) and only few had alcoholic cirrhosis (2/39), whereas no patients with hepatitis B virus infection and nine alcoholics of 18 cirrhotic patients (women/men: 6/12) were included in a previous study [25] . Histopathological examinations have shown that in the cirrhotic liver several sinusoids become capillarized and many terminal hepatic venules are distended [32,33] : the combination of these changes may lead to low-resistivity, high-speed vascular flow, with increased inflow and outflow. In addition, intrahepatic portal veins and hepatic veins cross cirrhotic areas, leading directly or indirectly into the central venous compartment.…”

Section: Groupmentioning

confidence: 99%

Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography

Chen¹,

Zeng²,

Huo³

et al. 2009

WJG

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AIM:To assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography (CT). METHODS:Perfusion CT was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis, proved by clinical and laboratory parameters. CT cine-scans were obtained over 50 s beginning with the injection of 50 mL of contrast agent. Hepatic microvascular parameters, mean transit time (MTT) and permeability surface area product (PS) were obtained with the Perfusion 3 software (General Electric, ADW 4.2). RESULTS:The overall differences of MTT and PS between control subjects, patients with compensated cirrhosis and those with decompensated cirrhosis were statistically significant (P = 0.010 and P = 0.002, respectively). MTT values were 15.613 ± 4.1746 s, 12.592 ± 4.7518 s, and 11.721 ± 4.5681 s for the three groups, respectively, while PS were 18.945 ± 7.2347 mL/min per 100 mL, 22.767 ± 8.3936 mL/min per 100 mL, and 28.735 ± 13.0654 mL/min per 100 mL. MTT in decompensated cirrhotic patients were significantly decreased compared to controls (P = 0.017), whereas PS values were remarkably increased (P = 0.001). CONCLUSION:The hepatic microvascular changes in patients with liver cirrhosis can be quantitatively assessed by perfusion CT. Hepatic microvascular parameters (MTT and PS), as measured by perfusion CT, were significantly altered in decompensated cirrhosis.

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Section: Groupmentioning

confidence: 99%