Intrahepatic Macrophage Reprogramming Associated with Lipid Metabolism in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure
Bo Peng,
Hao Li,
Kai Liu
et al.
Abstract:Background Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to the progression of ACLF, but the crosstalk between immunity and metabolism during ACLF is less understood. This study aims to depict the immune microenvironment in the liver during ACLF, and explore the role of lipid metabolic disorder on immunity.Methods Single-cell RNA-sequencing (scRNA-seq) was … Show more
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