Intrahepatic hepatitis C virus replication is increased in patients with regular alcohol consumption

Romero‐Gómez, Manuel; Grande, Lourdes; Nogales, M.C.; Fernández, Manuel; Diego, María José Chávez de; Castro, María José Romero

doi:10.1016/s1590-8658(01)80048-7

Cited by 41 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…63,81,[122][123][124][125][126] Strict birth control must be followed by both men and women. Interferon has abortifacient effects in animal studies and should not be used during pregnancy.…”

mentioning

confidence: 99%

Hepatitis C: a review for primary care physicians

Wong

Lee²

2006

Canadian Medical Association Journal

View full text Add to dashboard Cite

Primary care physicians see many of the estimated 250 000 Canadians chronically infected with the hepatitis C virus (HCV). Of this number, about one-third are unaware they are infected, which constitutes a large hidden epidemic. They continue to spread HCV unknowingly and cannot benefit from advances in antiviral therapy that may clear them of the virus. Many HCV-infected people remain asymptomatic, which means it is important to assess for risk factors and test patients accordingly. The third-generation enzyme immunoassay for HCV antibodies is a sensitive and specific test, although the presence of the virus can be confirmed by polymerase chain reaction testing for HCV RNA in some circumstances. Pegylated interferon-α and ribavirin combination therapy clears the virus in about 45%-80% of patients, depending on viral genotype. Preventive strategies and counselling recommendations are also reviewed. CMAJ 2006;174(5):649-59 Abstract

show abstract

mentioning

confidence: 99%

Hepatitis C: a review for primary care physicians

Wong

Lee²

2006

Canadian Medical Association Journal

View full text Add to dashboard Cite

show abstract

“…Several clinical studies have correlated increased serum HCV titer with the amount of alcohol consumed [141,[182][183][184][185][186]. HCV titer is significantly greater in patients consuming greater than 10g of alcohol per day [187].…”

Section: Alcohol Reactive Species and Hcv Replicationmentioning

confidence: 99%

“…Whether heavy, moderate, and light alcohol intake leads to consistent elevations in serum as well as intrahepatic HCV RNA is still unclear [188][189][190][191]. Nevertheless, alcohol can increase intrahepatic HCV RNA titer in patients [185,192] and subgenomic HCV RNA replication in vitro, in Huh7 human hepatoma cells, suggesting that alcohol may affect the viral life cycle itself [193].…”

Section: Alcohol Reactive Species and Hcv Replicationmentioning

confidence: 99%

Redox regulation of hepatitis C in nonalcoholic and alcoholic liver

Seronello

Sheikh²,

Choi

2007

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family that is estimated to have infected 170 million people worldwide. HCV can cause serious liver disease in humans such as cirrhosis, steatosis, and hepatocellular carcinoma. HCV induces a state of oxidative/nitrosative stress in patients through multiple mechanisms, and this redox perturbation has been recognized as a key player in the HCV-induced pathogenesis. Studies have shown that alcohol synergizes with HCV in the pathogenesis of liver disease, and part of these effects may be mediated by reactive species that are generated during hepatic metabolism of alcohol. Furthermore, reactive species and alcohol may influence HCV replication and the outcome of interferon therapy. Alcohol consumption has also been associated with increased sequence heterogeneity of the HCV RNA sequences, suggesting multiple modes of interaction between alcohol and HCV.This review summarizes current understanding of oxidative and nitrosative stress during HCV infection and possible combined effects of HCV, alcohol, and reactive species in the pathogenesis of liver disease.

show abstract

“…Some studies have shown that alcohol intake is associated with higher levels of HCV RNA, 1,21,25 but the actual increase was modest. Other studies have not found a difference in HCV RNA levels related to alcohol intake.…”

Section: Alcohol and Hcv Rnamentioning

confidence: 99%

Alcohol use and hepatitis C

2002

View full text Add to dashboard Cite

Excess alcohol consumption can worsen the course and outcome of chronic hepatitis C. It is important to distinguish between alcohol abuse, which must be treated on its own merits, and the effect of alcohol use on progression, severity, and treatment of hepatitis C. Most studies on the effects of alcohol on hepatitis C have focused on patients, with high levels of daily alcohol intake. Indeed, the adverse effects of light and moderate amounts of alcohol intake on hepatitis C virus (HCV) infection have not been clearly shown, and only limited studies have been performed. Sex differences exist in the effect of alcohol on fibrosis as well as on the severity of hepatitis C. Alcohol use has been reported to be associated with lower responses to therapy and, in some studies, higher HCV RNA levels and increased HCV quasi-species. Few studies address the treatment of hepatitis C in the alcoholic individual or determine the effect of continued light or moderate alcohol use on the outcome of treatment response. In summary, many critical questions remain regarding the interactions between alcohol and hepatitis C. Currently, the evidence from the literature shows that heavy alcohol intake worsens the outcome of HCV infection. The literature is inadequate to provide definitive recommendations regarding the effect of light to moderate alcohol use in patients with hepatitis C.Most studies of the effect of alcohol on hepatitis C have focused on persons who use 50 g/day or more of alcohol. These levels represent heavy alcohol intake and are typical of alcohol abuse. Many patients presenting to their healthcare provider for management of hepatitis C have not used alcohol at these levels. As will be discussed, many of these patients stop drinking after learning of their diagnosis but request information about the effects of light to moderate alcohol use on progression of their liver disease. This review will discuss current knowledge about alcohol and hepatitis C: where there is consensus, where there is confusion, and where future research studies are needed. Alcohol and Fibrosis Progression in Hepatitis C Virus InfectionHigh levels of excess alcohol intake worsen the course and outcome of chronic hepatitis C. 1-3 Poynard et al. 1 studied 1,574 patients with hepatitis C who had not received antiviral therapy but who had undergone liver biopsy and had an accurate history of alcohol intake. Alcohol consumption was assessed as none, moderate (0-49 g/day), and heavy (50 g/day or more). Irrespective of age or duration of infection, patients who drank more than 50 g daily Copyright © 2002 However, associations between increased fibrosis progression and the lower amounts of alcohol intake were not statistically significant, and measurements of alcohol intake were not performed in a uniform, standardized manner. Overall, the relative risk for progression of fibrosis with heavier alcohol intake was 2.36 (95% CI, 1.62-3.45; P = .0001). The investigators validated this model in a second group of 1,037 hepatitis C virus (HCV)-infect...

show abstract

Intrahepatic hepatitis C virus replication is increased in patients with regular alcohol consumption

Cited by 41 publications

References 26 publications

Hepatitis C: a review for primary care physicians

Hepatitis C: a review for primary care physicians

Redox regulation of hepatitis C in nonalcoholic and alcoholic liver

Alcohol use and hepatitis C

Contact Info

Product

Resources

About