Intrahepatic cholestasis in sickle cell disease: A review of diagnostic criteria, treatments, and case reports

Edwards, Christopher L.; Scott, Sharena; Boggan, Michaela; Meek, Jordan; Alston, Kiera; Pearson, Aiden; McDougald, Alexandria; Broadnax, McKenzie; Barker, Camela S.; Miller, J. Philip; Whitworth, Elaine; James, Osaffo; Sollers, John J.; Bryson, Walter; Thorpe, Roland J.; Byrd, Goldie S.; Whitfield, Keith E.; Sudhakar, Shiv; Parker, Debra O; Livingston, Jonathan; Shah, Nirmish; Railey, Kenyon

doi:10.1016/j.jnma.2022.12.004

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In consideration of the PRISMA guidelines that were updated in 2020, we began our exploration of papers related to PV for this review following a broader investigation of rare adult hematological manifestations in adults with SCD [45,46]. Our paper was based on reviews of papers from several databases to include Medline, Psychlit, PubMed, and google scholar.…”

Section: Discussionmentioning

confidence: 99%

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

Edwards,

Scott,

Boggan

et al. 2023

J Clin Haematol

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Objective: To delineate the etiology, symptomatology, and treatment of Polycythemia Vera in adults with Sickle Cell Disease. The current review contains a review of the 4 case reports that we found on the topic. To our knowledge, no other case reports exist. Methods: We reviewed the scientific literature to discover case reports that included the topic of PV. We noted consistencies in presentation, evaluation, treatment, and clinical outcomes. Results: We reviewed 4 case reports and a limited number of clinical papers on PV in SCD. We found and reported on consistencies in clinical presentation and the diversity of treatments. We reported hematological, bone marrow, and radiographic findings. Conclusions: There is great variability in the evaluation and treatment of cases of PV in SCD. We advocate for more research and deconstructing the complicated relationship between these two comorbid disorders.

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Section: Discussionmentioning

confidence: 99%

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

Edwards,

Scott,

Boggan

et al. 2023

J Clin Haematol

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Adult sickle cell disease and SARS-CoV-2: an increasingly common comorbidity for a rare disease

Boggan,

Edwards,

Meek

et al. 2024

Ital J Med

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Sickle cell disease (SCD) is a collection of genetic lesions that manifest in the diminished effectiveness of hemoglobin. We collected and reviewed the recent and extant literature on SARS-CoV-2 (COVID-19) and SCD. We posit an answer to the question associated with any adaptive responses to COVID-19 in individuals with SCD. We collected papers from MEDLINE and all available published papers on COVID-19 and SCD. Unlike a formal meta-analysis, given the early phase of this review in the pandemic, we did not seek unpublished papers. We found an emerging literature where case studies dominated, and traditional large N epidemiological studies were absent. Patients with SCD share many comorbid illnesses with an increased risk of mortality associated with contracting COVID-19. There is sufficient empirical justification to accelerate research on the impact of a viral pathogen like COVID-19 on individuals with SCD. *************************************************************** List of all authors: Michaela Boggan,1,2,3 Christopher L. Edwards,1,2,3 Jordan Meek,1,2,3 Mary Wood,4 W. Jeff Bryson,5 John J. Sollers,1,2,3 Debra O. Parker,1,2,3 Camela S. Barker,2,5 Jessica Miller,2,6 Brianna Downey,2,5 Asha Lockett,2,5 Jazmin Rosales,1,2,3 Courtney Munroe, Jr.,2 Noa Wax,2,5 Sharena Scott,1,2,3 Bridget Pittman,1,2,3 Merell Turner,1,2,3 Hillary T. Dietahin,1,2,3 Eric Smith,1,2,3 Alexandria McDougald,1,2,3 Samantha Beavers,1,2,3 Lakaiya Meadows,1,2,3 Maya Walker,1,2,3 Andrea Richardson,1,2,3 John J. Sollers, IV,2,8 Grace D. Donahue,2,8 Goldie Byrd,7 Malik Muhammad,1,2 Alvin Kidd,9 Walter Charles,1,2 Jonathan Livingston,1,2,3 Shiv Sudhakar10 1North Carolina Central University; 2NCCU Psychoneuroendocrine and Rare Diseases Laboratory; 3NCCU Debra O. Parker Research Incubator; 4Duke University Medical Center; 5Fielding Graduate University; 6Bridges Point Sickle Cell Foundation; 7Wake Forest Medical Center; 8Thomas Moore University; 9Livingston College; 10California Northstate University, United States

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Intrahepatic cholestasis in sickle cell disease: A review of diagnostic criteria, treatments, and case reports

Cited by 2 publications

References 17 publications

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

Adult sickle cell disease and SARS-CoV-2: an increasingly common comorbidity for a rare disease

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