Intrahepatic cholangiocarcinoma arising 28 years after excision of a type IV-A congenital choledochal cyst: report of a case

Kumamoto, Takafumi; Tanaka, Kuniya; Takeda, Kazuhisa; Nojiri, Kazunori; Mori, Rintaro; Taniguchi, Kouichi; Matsuyama, Ryusei; Ueda, Mitsuharu; Sugita, Mitsutaka; Ichikawa, Yasushi; Nagashima, Youji; Endo, Itaru

doi:10.1007/s00595-012-0387-2

Cited by 23 publications

(16 citation statements)

References 18 publications

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“…Shimamura et al and Kumamoto et al reported on tumor transformation following Todani type IVa choledochal cyst excision. 42,43 In contrast, Goto et al and Ng et al reported on malignancies following Todani type I cyst excision. 40,57…”

Section: Impact Of Initial Type Of Cystmentioning

confidence: 98%

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Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

et al. 2017

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Previous research has confirmed that patients with choledochal cyst have an elevated risk of cholangiocarcinoma and gallbladder carcinoma. Current data suggest a risk of malignancy of 6 to 30% in adults with choledochal cyst. Malignancy has also occasionally been identified in children and adolescents. Multiple factors, including the age of the patient, cyst type, histological findings, and localization, have an impact on the prognosis. Information on long-term outcomes after cyst excision is limited. However, recent data suggest a lifelong elevated risk of up to 4% of cancer development following operation. This paper presents a review of the literature on cancer in patients with choledochal cyst before and after excision. A postoperative follow-up concept that consists of annual controls of CA19-9 and abdominal ultrasound is introduced.

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Section: Impact Of Initial Type Of Cystmentioning

confidence: 98%

“…Ono et al reported on a 26-yearold man developing bile duct cancer following choledochal cyst excision at the age of 5 months. 28 43 The authors emphasized that no regular follow-ups had been performed during the 18 years between the second surgery and the diagnosis of cancer.…”

Section: Hepatobiliary Malignancies Following Choledochal Cyst Excisimentioning

confidence: 99%

Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

et al. 2017

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“…Several previous studies reported an association between choledochal cyst and cholangiocarcinoma [50,51]. Repeated damage and restoration of the biliary epithelium by regurgitation of pancreatic juice into the biliary system is presumed to be the cause of carcinogenesis [52]. Our meta-analysis showed that choledochal cyst is a strong risk factor for ICC.…”

Section: Discussionmentioning

confidence: 47%

Risk factors for intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Wang

Bin

et al. 2019

Preprint

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Background The incidence of intrahepatic cholangiocarcinoma (ICC) has increased worldwide in recent years, but the risk factors of ICC have not yet been clearly defined. The aim of this study was to identify risk factors for ICC. Methods A literature search was conducted in PubMed database for eligible studies published from January 2000 to November 2018. Summary odds ratio (OR) with their corresponding 95% confidence intervals (CI) were calculated using a random-effects model. Results Thirty-two studies (5 cohort, 27 case control) were included in this meta-analysis. Pooled estimates indicated that cirrhosis (OR=11.96, 95% CI 7.53-19.00), hepatitis B virus (HBV) infection (OR=4.09, 95% CI 3.13-5.34), hepatitis C virus (HCV) infection (OR=3.94, 95% CI 2.85-5.45), alcohol consumption (OR=2.68, 95% CI 1.97-3.66), hepatolithiasis (OR=14.94, 95% CI 6.41-34.83), choledochal cyst (OR=21.67, 95%CI 10.83-43.36), primary sclerosing cholangitis (PSC) (OR=93.91, 95%CI 43.99-200.47), diabetes mellitus (OR=1.82, 95% CI 1.57-2.11), non-alcoholic fatty liver disease (OR=2.23, 95% CI 1.65-3.02), liver fluke infection (OR=2.28, 95% CI 1.30-4.01) and smoking (OR=1.26, 95% CI 1.07-1.49) were significantly associated with ICC. Non-significant association was found between ICC and history of cholecystectomy, hypertension, coffee and aspirin. Conclusions Cirrhosis, HBV infection, HCV infection, alcohol consumption, hepatolithiasis, choledochal cyst, PSC, diabetes mellitus, non-alcoholic fatty liver disease, liver fluke infection and smoking are risk factors for ICC.

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“…ma developed in the intra-hepatic duct [6][7][8] and remaining stump after resection of a choledochal cyst. 8,9 The general CC diagnosis is reached in the pediatric patient and, currently, due to the accuracy of propaedeutic imaging methods, it is possible to be conducted intra-uterus.…”

Section: Reoperação Para Tratamento De Cisto De Colédoco No Adultomentioning

confidence: 99%

“…Type V cysts correspond to the Caroli disease. 18 On the basis of its association with cancer [3][4][5][6][7][8][9] , most authors have proposed surgical resection of type I and II choledochal cysts followed by traffic reconstruction of Roux in Y. [10][11][12][13]19 This conduct provides the best results, with low morbidity and mortality.…”

Section: Case Reportmentioning

confidence: 99%

Reoperation for the treatment of choledochal cyst in adults

Lisboa¹,

Salizi²,

Queiroz³

et al. 2015

Revista Médica De Minas Gerais

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Choledochal cyst refers to congenital dilatation of the main biliary route associated or not with the segmental intrahepatic ducts. We report the case of a female patient, 40 years old, with the diagnosis of choledochal cyst, who at 17 years of age had undergone surgical treatment. She evolved with cholangitis of repetition and obstructive jaundice. The imaging exams showed dilation of the biliary intra-hepatic routes, mainly on the left, hepatolithiasis, and a large cystic lesion in the liver pedicle. The laparotomy evidenced that the previous treatment had been a cholecystectomy and cyst draining through Roux cystojejunostomy in Y, which was blocked. The treatment consisted of resection of the choledochal cyst, hepatectomy of the 2 and 3 segments, and Roux hepaticojejunostomy in Y. The patient is in the fourth year of outpatient follow-up with no complications. On the basis of its association with cancer, resection and not just draining is the recommended treatment of choledochal cyst.

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Intrahepatic cholangiocarcinoma arising 28 years after excision of a type IV-A congenital choledochal cyst: report of a case

Cited by 23 publications

References 18 publications

Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

Risk factors for intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Reoperation for the treatment of choledochal cyst in adults

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