Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

Tan-Garcia, Alfonso; Wai, Lu-En; Zheng, Dahai; Ceccarello, Erica; Jo, Juandy; Banu, Nasirah; Khakpoor, Atefeh; Chia, Adeline; Tham, Christine Y.L.; Tan, Anthony T.; Hong, Michelle; Keng, Choong Tat; Rivino, Laura; Kc, Tan; Lee, Kang Hoe; Lim, Seng Gee; Newell, Evan W.; Pavelka, Norman; Chen, Jinmiao; Ginhoux, Florent; Chen, Yi‐Ping Phoebe; Bertoletti, Antonio; Dutertre, Charles–Antoine

doi:10.1016/j.jhep.2017.04.023

Cited by 57 publications

(60 citation statements)

References 51 publications

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“…In addition to the human immune system, recent progress has been made to introduce humanization of the liver in humanized mice to support the study of hepatotropic pathogens such as hepatitis B virus and hepatitis C virus (HCV) (Bility et al 2012; Keng et al 2015; Strick-Marchand et al 2015; Tan-Garcia et al 2017; Washburn et al 2011). It has been shown that these new humanized mice could be infected with human strains of hepatitis viruses and exhibit leukocyte infiltrations, liver inflammation, fibrosis, cirrhosis, and elevated cytokines similar to HCV-infected patients (Bility et al 2014; Keng et al 2015; Tan-Garcia et al 2017; Washburn et al 2011).…”

Section: Models Of Human Diseases Established On Humanized Micementioning

confidence: 99%

“…It has been shown that these new humanized mice could be infected with human strains of hepatitis viruses and exhibit leukocyte infiltrations, liver inflammation, fibrosis, cirrhosis, and elevated cytokines similar to HCV-infected patients (Bility et al 2014; Keng et al 2015; Tan-Garcia et al 2017; Washburn et al 2011). Mouse models with human liver cells and matched human immune system provides an important platform for understanding disease pathogenesis of hepatitis viruses through human-specific cytokines, chemokines and immune cell regulations involved, potentially translating this knowledge into creation of anti-fibrotic and immune-modulatory therapeutics (Bae et al 2015; Keng et al 2015).…”

Section: Models Of Human Diseases Established On Humanized Micementioning

confidence: 99%

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Humanized Mice as Unique Tools for Human-Specific Studies

Yong

Her

Chen

2018

Arch. Immunol. Ther. Exp.

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With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, “humanized” mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans. Currently, literature is rife with descriptions of novel and innovative humanized mouse models that hold a significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific therapeutics tested on this platform as well as solutions to improve humanized mice for future clinical use.

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Section: Models Of Human Diseases Established On Humanized Micementioning

confidence: 99%

Section: Models Of Human Diseases Established On Humanized Micementioning

confidence: 99%

Humanized Mice as Unique Tools for Human-Specific Studies

Yong

Her

Chen

2018

Arch. Immunol. Ther. Exp.

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“…Different populations of macrophages have recently been described in the liver of chronically infected animal models and patients. A study showed that end‐stage HBV liver disease is associated with an accumulation of CD14 + HLA‐DR hi CD206 + macrophages . These cells expressed spontaneously pro‐inflammatory markers (TNF‐α, GM‐CSF, Caspase 1…) and had a low expression of anti‐inflammatory markers (arginine 2, PPARG…) with the exception of IL‐10 which was increased .…”

Section: Interaction Between Liver Mφ and Hbvmentioning

confidence: 99%

Liver macrophages: Friend or foe during hepatitis B infection?

Faure-Dupuy

Durantel

Lucifora

2018

Liver International

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“…CD206, CD163 and CD204 are useful for M2 detection. Moreover, CD68 is considered a pan‐macrophage marker (Guo et al , ; Gustafson et al , ; Han et al , ; Motomura et al , ; Olesch et al , ; Salmi et al , ; Tan‐Garcia et al , ; Wang et al , ).…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used markers for M1 macrophages are CD11c, CD80 and HLA-DR. CD206, CD163 and CD204 are useful for M2 detection. Moreover, CD68 is considered a pan-macrophage marker (Guo et al, 2018;Gustafson et al, 2015;Han et al, 2016;Motomura et al, 2015;Olesch et al, 2015;Salmi et al, 2018;Tan-Garcia et al, 2017;Wang et al, 2014a).…”

Section: Introductionmentioning

confidence: 99%

RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF‐κB pathway in oral squamous cell carcinoma

et al. 2020

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Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell carcinoma (OSCC) progression, and RACK1 expression levels have been negatively correlated with prognosis in patients with OSCC. Here, we investigated the impact of RACK1 OSCC expression on the recruitment and differentiation of tumor‐associated macrophages. High RACK1 expression in OSCC cells correlated with increased M2 macrophage infiltration in tumor samples from a clinical cohort study. Moreover, the combination of RACK1 expression and the M2/M1 ratio could successfully predict prognosis in OSCC. OSCC cells with high RACK1 expression inhibited the migration of THP‐1 cells, promoted M2‐like macrophage polarization in vitro, and increased the proportion of M2‐like macrophages in a xenograft mouse model. Moreover, both M1‐ and M2‐like macrophage polarization‐associated proteins were induced in macrophages cocultured with RACK1‐silenced cell supernatant. A mechanistic study revealed that the expression and secretion of C‐C motif chemokine 2 (CCL2), C‐C motif chemokine 5 (CCL5), interleukin‐6 (IL‐6), and interleukin‐1 (IL‐1) are closely related to RACK1 expression. In addition, blocking nuclear factor‐kappa B (NF‐κB) could promote M2‐like macrophage polarization. These results indicate that RACK1 and the M2/M1 ratio are predictors of a poor prognosis in OSCC. RACK1 promotes M2‐like polarization by regulating NF‐κB and could be used as a potential therapeutic target for antitumor immunity.

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Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

Cited by 57 publications

References 51 publications

Humanized Mice as Unique Tools for Human-Specific Studies

Humanized Mice as Unique Tools for Human-Specific Studies

Liver macrophages: Friend or foe during hepatitis B infection?

RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF‐κB pathway in oral squamous cell carcinoma

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