Intrahepatic Carcinosarcoma With Cholangiocarcinoma Elements and Prominent Bile Duct Spread

Usui, Genki; Hashimoto, Hirotsugu; Kusakabe, Makoto; Shirota, Go; Sugiura, Yoshiya; Fujita, Yuji; Satou, Shouichi; Harihara, Yasushi; Horiuchi, Hajime; Morikawa, Teppei

doi:10.1177/1066896919855766

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…ESOS accounts for 1% of all soft tissue sarcomas and 4% of osteogenic osteosarcomas[ 5 ]. ESOS is characterized by invasive growth, a high likelihood of metastasis and recurrence, and a poor prognosis[ 1 ]. The initial clinical symptom is usually a painless mass[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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Relapsed primary extraskeletal osteosarcoma of liver: A case report and review of literature

Di¹,

Long²,

Ning³

et al. 2023

World J Clin Cases

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BACKGROUND Extraskeletal osteosarcoma (ESOS) is a highly malignant osteosarcoma that occurs in extraskeletal tissues. It often affects the soft tissues of the limbs. ESOS is classified as primary or secondary. Here, we report a case of primary hepatic osteosarcoma in a 76-year-old male patient, which is very rare. CASE SUMMARY Here, we report a case of primary hepatic osteosarcoma in a 76-year-old male patient. The patient had a giant cystic-solid mass in the right hepatic lobe that was evident on ultrasound and computed tomography. Postoperative pathology and immunohistochemistry of the mass, which was surgically removed, suggested fibroblastic osteosarcoma. Hepatic osteosarcoma reoccurred 48 d after surgery, resulting in significant compression and narrowing of the hepatic segment of the inferior vena cava. Consequently, the patient underwent stent implantation in the inferior vena cava and transcatheter arterial chemoembolization. Unfortunately, the patient died of multiple organ failure postoperatively. CONCLUSION ESOS is a rare mesenchymal tumor with a short course and a high likelihood of metastasis and recurrence. The combination of surgical resection and chemotherapy may be the best treatment.

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Section: Discussionmentioning

confidence: 99%

“…Extraskeletal osteosarcoma (ESOS) is a highly malignant osteosarcoma that occurs in extraosseous tissues. It is characterized by a low incidence, invasive growth, a high likelihood of metastasis and recurrence, and a poor prognosis[ 1 ]. ESOS often involves the soft tissues of the limbs.…”

Section: Introductionmentioning

confidence: 99%

Relapsed primary extraskeletal osteosarcoma of liver: A case report and review of literature

Di¹,

Long²,

Ning³

et al. 2023

World J Clin Cases

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“…Compared with the above recurrence, MRI has the advantages of good tissue resolution, no radiation, and 9 Computational and Mathematical Methods in Medicine MRI signal not affected by lipiodol. It has gradually received extensive attention and application in the diagnosis and efficacy evaluation of liver cancer [27][28][29]. DWI can detect the motion state of water molecules in biological tissues, and the motion state of water molecules is closely related to tissue structure, biochemical properties, intracellular and extracellular volume changes, and extracellular space morphological changes.…”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis of Primary Liver Cancer Using Magnetic Resonance Dilated Weighted Imaging and the Treatment Effect of Sorafenib

Fan

Zhang

Guo³

2022

Computational and Mathematical Methods in Medicine

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Objective. This work explores the application value of dilated weighted imaging (DWI) in the diagnosis of primary liver cancer (PLC) and the effect of sorafenib in the treatment of PLC. Methods. 88 patients with PLC who were treated in The First Affiliated Hospital of Northwest University from March 2019 to March 2021 were selected and randomly rolled into an experimental group and a control group, with 44 cases in each group. Patients in both groups were treated with transcatheter arterial chemoembolization (TACE), and the patients in the experimental group were treated with oral sorafenib on the basis of TACE. The indicators of complications, short-term efficacy (STE), and long-term efficacy (LTE) of the two groups were observed. All patients received DWI and magnetic resonance (MR) plain scan. The diagnostic accuracy and misdiagnosis rate of the two methods in diagnosing the PLC were compared. Results. The accuracy, specificity, and sensitivity of MR plain scan were 68%, 88%, and 89%, respectively, while those of DWI were 96%, 95%, and 94.2%, respectively. It indicated that the accuracy, specificity, and sensitivity of DWI in diagnosing lesions were better than those of MR plain scan, especially the diagnostic accuracy ( P < 0.05 ). The objective response rate (ORR) and disease control rate (DCR) of the STE in the experimental group were 30% and 97%, respectively, and those in the control group were 6% and 54.5%, respectively. The experimental group’s mean progression-free survival (mPFS) and mean overall survival (mOS) were 12 and 25 months, respectively, while the control group’s were 8 and 19 months, respectively. It was concluded that the mPFS and mOS of patients receiving TACE combined with oral sorafenib were much higher than those receiving TACE only ( P < 0.05 ). Conclusion. DWI and TACE combined with sorafenib had high application value in the diagnosis and treatment of PLC.

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“…In the retrospective literature, 24 articles 2,3,[7][8][9][10][11]13,14,17,[19][20][21][22][23][24][26][27][28][29][30][31][32][33] were involved in the imaging manifestations, including our study of total of 35 patients. Due to the different proportion of carcinomatous components and sarcomatous components in HCS, and their pathological types were not the same, the imaging manifestations were different.…”

Section: Discussionmentioning

confidence: 99%

<p>The Clinicopathological and Imaging Characteristics of Primary Hepatic Carcinosarcoma and a Review of the Literature</p>

Bin

Chen

Peng

et al. 2020

JHC

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Purpose: To improve the understanding of hepatic carcinosarcoma (HCS) by analyzing radiological imaging data and clinicopathological features. Materials and Methods: A retrospective analysis was performed on four patients with HCS confirmed immunohistochemically. The analysis included three males and one female, aged 29 to 64 years. Four patients underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging (MRI) scans simultaneously. Results: Three patients had a history of hepatitis B, cirrhosis or fibrosis, and two patients had schistosomiasis. Two cases tested positive for elevated serum carbohydrate antigen (CA) 19-9. The maximum diameters of the lesions ranged from 7.8 to 9.0cm. Pathologically, the carcinomatous and sarcomatous elements in two patients could not be classified, one of the patients had cholangiocellular carcinoma (CCC) and undifferentiated sarcoma, the other had hepatocellular carcinoma (HCC) and undifferentiated pleomorphic sarcoma (UPS). All tumors showed heterogeneous density/intensity, accompanied by vast cystic changes and necrosis, with two cases having cystic septations. Capsule formation was not identified. The margins of the radiological images showed irregular ring enhancement. One case presented continuous progressive enhancement, one case with "fast in fast washout" and two cases with "fast in late washout". Lymphonodus metastasis, satellite nodules, vascular embolism, and organ invasion (hepatic flexure of the colon) were identified. Conclusion: HCS is a rare, high-grade malignancy with poor prognosis. The preoperative diagnosis is expected to improve by carefully analyzing the imaging features of the patients in combination with their clinical characteristics. Radical resection and postoperative chemoradiotherapy can improve the survival rate of patients.

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Intrahepatic Carcinosarcoma With Cholangiocarcinoma Elements and Prominent Bile Duct Spread

Cited by 7 publications

References 15 publications

Relapsed primary extraskeletal osteosarcoma of liver: A case report and review of literature

Relapsed primary extraskeletal osteosarcoma of liver: A case report and review of literature

Imaging Diagnosis of Primary Liver Cancer Using Magnetic Resonance Dilated Weighted Imaging and the Treatment Effect of Sorafenib

<p>The Clinicopathological and Imaging Characteristics of Primary Hepatic Carcinosarcoma and a Review of the Literature</p>

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